33.75 mg \/ 150 mg and 45 mg \/ 200 mg coated granules in sachets
ledipasvir \/ sofosbuvir<\/p>\n\n\n\n
Harvoni is a medicine that contains the active substances ledipasvir and sofosbuvir in the form of a granulate. Harvoni was given to treat chronic (long-term) infection with hepatitis C virus in adults<\/strong> and children from 3 years of age<\/strong>.<\/p>\n\n\n\n Hepatitis C is an infection of the liver caused by a virus. The active substances in the medicine work together by blocking two different proteins that the virus needs to grow and reproduce, which makes it possible to permanently remove an infection from the body.<\/p>\n\n\n\n Harvoni is sometimes taken with another medicine, ribavirin.<\/p>\n\n\n\n It is very important that you also read the package leaflets for the other medicines that you are taking with Harvoni. If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n \u2192 If any of these apply to you, do not take Harvoni but tell your doctor immediately.<\/strong><\/p>\n\n\n\n Your doctor knows if you have any of the following conditions. These will be considered before starting treatment with Harvoni.<\/p>\n\n\n\n Talk to your doctor or pharmacist before taking Harvoni if:<\/p>\n\n\n\n Tell<\/strong> your doctor immediately if<\/strong> you are currently taking, or have taken any medicines for heart problems in the last few months, and your experience during treatment:<\/p>\n\n\n\n Blood tests<\/strong><\/p>\n\n\n\n Your doctor will examine your blood before, during, and after treatment with Harvoni to:<\/p>\n\n\n\n Do not give this medicine to children under 3 years. The use of Harvoni in children under 3 years of age has not yet been studied.<\/p>\n\n\n\n Tell<\/strong> your doctor or pharmacist<\/strong> if you have recently taken or might take any other medicines.<\/p>\n\n\n\n Warfarin and other similar medicines called vitamin K antagonists are used to thin the blood. Your doctor may need to test your blood more often to check your blood coagulation ability.<\/p>\n\n\n\n The function of your liver can change with the treatment of hepatitis C and can therefore affect other drugs (eg drugs used to inhibit your immune system, etc.). Your doctor may need to monitor these other medicines that you are taking care and adjustments may need to be made after starting treatment with Harvoni.<\/p>\n\n\n\n Talk to your doctor or pharmacist if you are not sure if you should take any medicine.<\/p>\n\n\n\n Some medicines should not be taken with Harvoni.<\/strong><\/p>\n\n\n\n If you take Harvoni with any of these medicines, your medicines may not work properly or any side effects may get worse. Your doctor may need to give you another medicine or change the dose of medicine you are taking.<\/p>\n\n\n\n These medicines may reduce the amount of ledipasvir in your blood. If you are taking any of these medicines, your doctor will either give you another medicine for stomach ulcers, heartburn, or acid reflux or recommend how and when to take it.<\/p>\n\n\n\n The effect of Harvoni during pregnancy is unknown. If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n Pregnancy must be avoided if you take Harvoni with ribavirin. You must read the section \u201cPregnancy\u201d in the package leaflet of ribavirin very carefully. Ribavirin can cause serious birth defects. Therefore, special precautions must be taken during sexual intercourse if there is a risk of pregnancy occurring.<\/p>\n\n\n\n Breast-feeding<\/strong><\/p>\n\n\n\n Do not breastfeed during treatment with Harvoni. <\/strong>It is not known whether ledipasvir or sofosbuvir, the two active substances in Harvoni, pass into breast milk.<\/p>\n\n\n\n If you feel tired after taking Harvoni, do not engage in activities that require concentration, such as driving, cycling, or using machines.<\/p>\n\n\n\n Harvoni granules contain lactose<\/strong><\/p>\n\n\n\n Harvoni granules contain sodium<\/strong><\/p>\n\n\n\n Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n Recommended dose<\/strong><\/p>\n\n\n\n Harvoni should be taken according to the doctor’s instructions. <\/strong>Your doctor will tell you how long to take Harvoni and how many sachets to take.<\/p>\n\n\n\n The recommended dose of Harvoni is the entire contents of the sachet (s) once daily<\/strong> with or without food.<\/p>\n\n\n\n Intake of Harvoni granules with food to facilitate swallowing:<\/strong><\/p>\n\n\n\n 1. Hold the sachet with the dashed line facing up.<\/p>\n\n\n\n 2. Shake the sachet gently to collect the contents on the bottom.<\/p>\n\n\n\n Tear or cut along the dotted line to open the sachet.<\/p>\n\n\n\n 4. Carefully pour all the contents of the sachet onto one or more spoons of non-acidic food, e.g. chocolate sauce, mashed potatoes, or ice cream, at or below room temperature.<\/p>\n\n\n\n 5. Check that there are no granules left in the sachet.<\/p>\n\n\n\n 6. Take all granules within 30 minutes after gently mixing with food.<\/p>\n\n\n\n 7. Swallow a mixture of food and granules without chewing to avoid the bitter taste. Make sure all food is swallowed.<\/p>\n\n\n\n Taking Harvoni without food or water or with water to facilitate swallowing:<\/strong><\/p>\n\n\n\n 1. Hold the sachet with the dashed line facing up.<\/p>\n\n\n\n 2. Shake the sachet gently to collect the contents on the bottom.<\/p>\n\n\n\n Tear or cut along the dotted line to open the sachet.<\/p>\n\n\n\n The granules can be taken directly into the mouth and swallowed without chewing to avoid the bitter taste or with a liquid that is not acidic, e.g. water. Do not use<\/strong> fruit juices, e.g. apple, cranberry, grapefruit, orange, or pineapple juices, as they are acidic and should not be used.<\/p>\n\n\n\n 5. Check that there are no granules left in the sachet.<\/p>\n\n\n\n 6. Swallow all granules.<\/p>\n\n\n\n If you are taking an antacid,<\/strong> take it at least 4 hours before or at least 4 hours after Harvoni.<\/p>\n\n\n\n If you are taking a proton<\/strong> pump inhibitor,<\/strong> take the proton pump inhibitor at the same time as Harvoni. Do not take it before Harvoni.<\/p>\n\n\n\n If you vomit after taking Harvoni<\/strong>, it may affect the amount of Harvoni in your blood. This may mean that Harvoni does not work as well.<\/p>\n\n\n\n If you accidentally take more than the recommended dose, contact your doctor or nearest emergency department immediately for advice. Bring the sachet and the box with you so that you can easily describe what you have taken.<\/p>\n\n\n\n It is important that you do not miss a dose of this medicine.<\/p>\n\n\n\n If you miss a dose, calculate how long it has been since you last took Harvoni:<\/p>\n\n\n\n Do not stop taking this medicine unless your doctor tells you to. It is very important that you complete the entire course of treatment to give the medicine the best conditions to treat an infection with the hepatitis C virus.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause side effects, although not everybody gets them. If you take Harvoni, you may experience one or more of the following side effects:<\/p>\n\n\n\n Very common side effects are<\/strong><\/p>\n\n\n\n ( may affect more than 1 in 10 people<\/em> )<\/p>\n\n\n\n Common side effects are<\/strong><\/p>\n\n\n\n ( may affect up to 1 in 10 people<\/em> )<\/p>\n\n\n\n Other side effects that may occur during treatment with Harvoni<\/strong><\/p>\n\n\n\n The frequency of the following side effects is unknown (cannot be calculated from the available data):<\/p>\n\n\n\n Other effects that can be seen with sofosbuvir treatment:<\/strong><\/p>\n\n\n\n The frequency of the following side effects is unknown (cannot be calculated from the available data):<\/p>\n\n\n\n Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist, or nurse. This also applies to any side effects not mentioned in this information. You can also report side effects directly to the Medical Products Agency. By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the can and carton after \u201cEXP\u201d. The expiration date is the last day of the specified month.<\/p>\n\n\n\n No special storage instructions.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n The active substances are ledipasvir and sofosbuvir.<\/strong><\/p>\n\n\n\n Granules are orange and are in a sachet.<\/p>\n\n\n\n The following pack sizes are available:<\/p>\n\n\n\n Gilead Sciences Ireland UC<\/p>\n\n\n\n Carrigtohill<\/p>\n\n\n\n County Cork, T45 DP77<\/p>\n\n\n\n Ireland<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n Gilead Sciences Ireland UC<\/p>\n\n\n\n IDA Business & Technology Park<\/p>\n\n\n\n Carrigtohill<\/p>\n\n\n\n County Cork<\/p>\n\n\n\n Ireland<\/p>\n","protected":false},"excerpt":{"rendered":" Harvoni is a medicine that contains the active substances ledipasvir and sofosbuvir in the form of a granulate. Harvoni was given to treat chronic (long-term) infection with hepatitis C virus in adults and children from 3 years of age.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[13937,13932,13928,13934,13938,13929,13933,4083,4085,13936,13935,13930,4084,13931,13927],"class_list":["post-13727","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-harvoni","tag-benefits-of-ledipasvir","tag-benefits-of-sofosbuvir","tag-harvoni","tag-harvoni-side-effects","tag-ledipasvir","tag-ledipasvir-side-effects","tag-sofosbuvir","tag-sofosbuvir-side-effects","tag-what-harvoni-is-used-for","tag-what-is-harvoni","tag-what-is-ledipasvir","tag-what-is-sofosbuvir","tag-what-ledipasvir-is-used-for","tag-what-sofosbuvir-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13727"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13727\/revisions"}],"predecessor-version":[{"id":15324,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13727\/revisions\/15324"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}2. What you need to know before using Harvoni<\/h2>\n\n\n\n
Do not use Harvoni<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Other medicines and Harvoni<\/h2>\n\n\n\n
Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Harvoni contains copovidone, lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate, hypromellose, talc, titanium dioxide, macrogol, yellow iron oxide, red iron oxide, amino-methacrylate copolymer<\/h2>\n\n\n\n
3. How to use Harvoni<\/h2>\n\n\n\n
If you use more Harvoni than you should <\/h2>\n\n\n\n
If you forget to use Harvoni<\/h2>\n\n\n\n
If you stop using Harvoni<\/h2>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
5. How to store Harvoni<\/h2>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n