{"id":13691,"date":"2021-09-18T16:13:34","date_gmt":"2021-09-18T16:13:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13691"},"modified":"2021-11-03T11:44:52","modified_gmt":"2021-11-03T11:44:52","slug":"granisetron-fresenius-kabi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/granisetron-fresenius-kabi\/","title":{"rendered":"Granisetron Fresenius Kabi &#8211; Granisetron uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg \/ ml&nbsp;injection&nbsp;solution<br>Granisetron<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Granisetron Fresenius Kabi is and what it is used for<\/h2>\n\n\n\n<p>Granisetron Fresenius Kabi contains the active substance granisetron.&nbsp;It belongs to a group of medicines called &#8220;5-HT&nbsp;<sub>3<\/sub>&nbsp;receptor antagonists&#8221; or &#8220;antiemetics&#8221; (medicines that prevent nausea and vomiting).<\/p>\n\n\n\n<p>Granisetron Fresenius Kabi is used to prevent and treat nausea and vomiting caused by other medical treatments, such as chemotherapy and radiation therapy for cancer and&nbsp;surgery.<\/p>\n\n\n\n<p>Solution for&nbsp;injection&nbsp;is used for adults and children aged 2 years and older.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Granisetron Fresenius Kabi<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Granisetron Fresenius Kabi<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to granisetron or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If you are not sure, talk to a doctor, pharmacist, or nurse before getting an&nbsp;injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Granisetron Fresenius Kabi if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have problems with your bowel movements due to blockages in the intestines.<\/li><li>have heart problems, are treated for cancer with a drug that is known to be harmful to the heart or have problems with salt levels in the body, such as&nbsp;potassium&nbsp;,&nbsp;sodium&nbsp;or&nbsp;calcium&nbsp;(electrolyte changes).<\/li><li>take another medicine that is \u201c5-HT&nbsp;<sub>3<\/sub>&nbsp;receptor antagonists\u201d.&nbsp;This includes dolasetron, ondansetron which is used in the same way as Granisetron Fresenius Kabi to treat and prevent nausea and vomiting.<\/li><\/ul>\n\n\n\n<p>Serotonin syndrome is a less common but possibly life-threatening reaction that may occur with the use of granisetron (see section 4).&nbsp;The reaction may occur if you take granisetron alone but are more likely if you take granisetron with certain other medicines (especially&nbsp;fluoxetine&nbsp;,&nbsp;paroxetine&nbsp;,&nbsp;sertraline&nbsp;, fluvoxamine,&nbsp;citalopram&nbsp;, escitalopram, venlaflaxine, duloxetine).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Granisetron Fresenius Kabi<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines.&nbsp;This is because Granisetron Fresenius Kabi can affect the way some medicines work.&nbsp;Some other medicines may also affect the way Granisetron Fresenius Kabi&nbsp;injection&nbsp;works.<\/p>\n\n\n\n<p>In particular, tell your doctor, pharmacist, or nurse if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs used to treat irregular heartbeats<\/li><li>other medicines that are \u201c5-HT&nbsp;<sub>3<\/sub>&nbsp;receptor antagonists\u201d such as dolasetron or ondansetron (see \u201cWarnings and Precautions\u201d above)<\/li><li>phenobarbital, a drug used to treat&nbsp;epilepsy<\/li><li>a drug called&nbsp;ketoconazole&nbsp;used to treat fungal infections<\/li><li>the antibiotic erythromycin used to treat bacterial infections<\/li><li>SSRIs&nbsp;(selective serotonin reuptake inhibitors) used to treat depression and \/ or anxiety.&nbsp;For example&nbsp;fluoxetine&nbsp;,&nbsp;paroxetine&nbsp;,&nbsp;sertraline&nbsp;, fluvoxamine,&nbsp;citalopram&nbsp;, escitalopram &nbsp;<\/li><li>SNRIs&nbsp;(&nbsp;serotonin&nbsp;noradrenaline uptake inhibitors) used to treat depression and \/ or anxiety.&nbsp;For example venlaflaxine, duloxetine<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Granisetron Fresenius Kabi is unlikely to affect your ability to drive and use tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Granisetron Fresenius Kabi contains sodium chloride<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per&nbsp;ampoule, ie essentially &#8216;sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Granisetron Fresenius Kabi<\/h2>\n\n\n\n<p>A doctor or nurse will give you an&nbsp;injection.&nbsp;Dosage&nbsp;one varies from one patient to another.&nbsp;It depends on your age, weight, and whether you are receiving the medicine to prevent or treat nausea and vomiting.&nbsp;Your doctor will calculate the&nbsp;dose&nbsp;you should receive.<\/p>\n\n\n\n<p>Granisetron Fresenius Kabi is given as an&nbsp;injection&nbsp;into the veins (&nbsp;intravenously&nbsp;).<\/p>\n\n\n\n<p><strong>To prevent nausea or vomiting after radiation or chemotherapy<\/strong><\/p>\n\n\n\n<p>You will receive an&nbsp;injection&nbsp;before the radiation or chemotherapy treatment is started.&nbsp;Injection&nbsp;one into the veins will take between 30 seconds and 5 minutes and&nbsp;dose&nbsp;one will usually be between 1 and 3 mg.&nbsp;The drug will be diluted before being injected.<\/p>\n\n\n\n<p><strong>Treatment for nausea or vomiting after radiotherapy or chemotherapy<\/strong><\/p>\n\n\n\n<p>Injection&nbsp;one will take between 30 seconds and 5 minutes and&nbsp;dose&nbsp;one will usually be between 1 and 3 mg.&nbsp;The medicine will be diluted before being injected into your veins.&nbsp;After receiving the first&nbsp;dose, you may be given more&nbsp;injections&nbsp;to stop nausea.&nbsp;There will be at least 10 minutes between each&nbsp;injection.&nbsp;The highest&nbsp;dose&nbsp;of Granisetron Fresenius Kabi that you receive is 9 mg per day.<\/p>\n\n\n\n<p><strong>Combination with&nbsp;steroids&nbsp;is<\/strong><\/p>\n\n\n\n<p>The effect of&nbsp;injection&nbsp;can be enhanced by the use of drugs called&nbsp;corticosteroids.&nbsp;Steroid&nbsp;one can either be given with a&nbsp;dose&nbsp;between 8 and 20 mg <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a> before the radiation or chemotherapy treatment starts or as 250 mg methylprednisolone which will be given both before and after your radiation or chemotherapy treatment.<\/p>\n\n\n\n<p><strong>Treatment of nausea or vomiting after&nbsp;surgery<\/strong><\/p>\n\n\n\n<p>Injection&nbsp;one into the veins will take between 30 seconds and 5 minutes and&nbsp;dose&nbsp;one is usually 1 mg.&nbsp;The highest&nbsp;dose of&nbsp;Granisetron Fresenius Kabi that will be given is 3 mg per day.<\/p>\n\n\n\n<p><strong>Use in children<\/strong><\/p>\n\n\n\n<p><strong>Use in children to prevent or treat nausea or vomiting after radiotherapy or chemotherapy<\/strong><\/p>\n\n\n\n<p>Children will receive Granisetron Fresenius Kabi by&nbsp;injection&nbsp;into their vein as described above.&nbsp;Dose&nbsp;one depends on the weight of the child.&nbsp;The solution for injection will be diluted and given before starting radiation therapy or chemotherapy.&nbsp;Injection&nbsp;one will take 5 minutes.&nbsp;Children will receive a maximum of 2 doses per day at least 10 minutes apart.<\/p>\n\n\n\n<p><strong>Use in children to prevent or treat nausea or vomiting after&nbsp;surgery<\/strong><\/p>\n\n\n\n<p>Children should not be given this&nbsp;injection&nbsp;to treat nausea or vomiting after&nbsp;surgery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Granisetron Fresenius Kabi than you should&nbsp;<\/h2>\n\n\n\n<p>As an&nbsp;injection&nbsp;is given to you by a doctor or nurse, it is unlikely that you will receive an&nbsp;overdose.&nbsp;Talk to your doctor or nurse if you are worried.&nbsp;The symptoms of overdose are a mild headache.&nbsp;You will be treated depending on your symptoms.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;If you notice any of the following problems, see&nbsp;a doctor&nbsp;<strong>immediately<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions (&nbsp;anaphylaxis&nbsp;).&nbsp;Signs of this may be swelling of the throat, face, lips and mouth, difficulty breathing and swallowing.<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur when you take this medicine are:<\/p>\n\n\n\n<p>Very common: may affect more than 1 in 10 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>constipation.&nbsp;Your doctor will examine you.<\/li><\/ul>\n\n\n\n<p>Common: may affect up to 1 to 10 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sleep problems (insomnia)<\/li><li>Changes in the way your liver works are shown by blood tests<\/li><li>diarrhea<\/li><\/ul>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>skin rash or an allergic skin reaction or&nbsp;hives&nbsp;(&nbsp;urticaria&nbsp;).&nbsp;Signs of this may be red, raised itchy rashes.<\/li><li>altered heartbeat (rhythm) and changes seen on&nbsp;ECG&nbsp;(electrical recording of the heart)<\/li><li>abnormal involuntary movements such as tremors, muscle stiffness and muscle contractions.<\/li><li>Serotonin syndrome.&nbsp;Symptoms may include diarrhea, nausea, vomiting, fever, high&nbsp;blood pressure&nbsp;, excessive sweating and rapid&nbsp;heartbeat&nbsp;, agitation, confusion, hallucinations, chills, muscle tremors, twitching or stiffness, loss of coordination and restlessness.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;&nbsp;By reporting side effects, you can help increase drug safety information.<a href=\"javascript:void(0);\">&nbsp;<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Granisetron Fresenius Kabi<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and\/or ampoule label after EXP.&nbsp;date.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Once Granisetron Fresenius Kabi has been opened, it should be used immediately.<\/p>\n\n\n\n<p>When Granisetron Fresenius Kabi has been diluted, it should be used immediately.&nbsp;If the reconstituted solution is not used immediately, it should be stored at 25 \u00b0 C, protected from sunlight, and used within 24 hours.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is granisetron (as hydrochloride).Each ml of&nbsp;solution for injection&nbsp;contains 1 mg of granisetron (as hydrochloride).<\/li><li>The other ingredients are citric acid monohydrate,&nbsp;hydrochloric acid&nbsp;, sodium chloride, water for injections and sodium hydroxide for&nbsp;pH&nbsp;regulation&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Granisetron Fresenius Kabi is a clear, colorless liquid.<\/p>\n\n\n\n<p>The package may contain 5 or 10 ampoules in clear glass.&nbsp;The ampoules&nbsp;contain either 1 ml or 3 ml Granisetron Fresenius Kabi 1 mg\/ml&nbsp;solution for injection.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Fresenius Kabi AB<\/p>\n\n\n\n<p>751 74 Uppsala<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Labesfal &#8211; Laboratories Almiro SA (Fresenius Kabi Group)<\/p>\n\n\n\n<p>Lagedo Industrial Zone<\/p>\n\n\n\n<p>3465-157 Santiago de Besteiros<\/p>\n\n\n\n<p>Portugal<\/p>\n\n\n\n<p>and<\/p>\n\n\n\n<p>Fresenius Kabi Austria GmbH<\/p>\n\n\n\n<p>Hafnerstrasse 36<\/p>\n\n\n\n<p>A-8055 Graz<\/p>\n\n\n\n<p>Austria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Granisetron Fresenius Kabi contains the active substance granisetron. It belongs to a group of medicines called &#8220;5-HT 3 receptor antagonists&#8221; or &#8220;antiemetics&#8221; (medicines that prevent nausea and vomiting).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14073,13703,14056,14069,14074,14068,14061,14071,14058,14057,14070],"class_list":["post-13691","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-granisetron-fresenius-kabi","tag-benefits-of-v","tag-granisetron","tag-granisetron-fresenius-kabi","tag-granisetron-fresenius-kabi-side-effects","tag-granisetron-injection","tag-granisetron-side-effects","tag-what-granisetron-fresenius-kabi-is-used-for","tag-what-granisetron-is-used-for","tag-what-is-granisetron","tag-what-is-granisetron-fresenius-kabi"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13691"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13691\/revisions"}],"predecessor-version":[{"id":15391,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13691\/revisions\/15391"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}