{"id":13685,"date":"2021-09-18T16:09:17","date_gmt":"2021-09-18T16:09:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13685"},"modified":"2021-11-03T11:45:15","modified_gmt":"2021-11-03T11:45:15","slug":"gonapeptyl","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/gonapeptyl\/","title":{"rendered":"Gonapeptyl &#8211; Triptorelin uses, dose and side effects"},"content":{"rendered":"\n<p>0.1 mg \/ ml&nbsp;injection&nbsp;solution<br>triptorelin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Gonapeptyl is and what it is used for<\/h2>\n\n\n\n<p>This medicine is supplied as a&nbsp;syringe&nbsp;in a&nbsp;single-use&nbsp;syringe.&nbsp;It is given as an&nbsp;injection&nbsp;under the skin in the lower abdomen.<\/p>\n\n\n\n<p>This medicine contains triptorelin, a chemically produced equivalent of the natural&nbsp;hormone&nbsp;et&nbsp;GnRH&nbsp;(gonadotropin-releasing&nbsp;hormone&nbsp;).&nbsp;GnRH&nbsp;regulates the secretion of sex hormones in the body (so-called&nbsp;gonadotropins&nbsp;):&nbsp;luteinizing hormone&nbsp;(&nbsp;LH&nbsp;) and follicle-stimulating&nbsp;hormone&nbsp;(&nbsp;FSH&nbsp;).&nbsp;Gonapeptyl blocks the effect of&nbsp;GnRH.&nbsp;This reduces the levels of&nbsp;LH&nbsp;and&nbsp;FSH&nbsp;(so-called down-regulation).&nbsp;This prevents premature ovulation.<\/p>\n\n\n\n<p>This medicine is used to treat women in assisted reproduction (ART).&nbsp;In assisted reproduction, ovulation sometimes occurs prematurely, and then the chance of pregnancy decreases.&nbsp;GONAPEPTYL is used for downregulation and prevention of premature&nbsp;LH&nbsp;&#8211;&nbsp;release, which could cause such premature ovulation.<\/p>\n\n\n\n<p>Triptorelin contained in Gonapeptyl may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Gonapeptyl<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Gonapeptyl<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to&nbsp;<strong>triptorelin acetate<\/strong>&nbsp;or any of the other ingredients of this medicine (see section 6 &#8220;Other information&#8221;)<\/li><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to&nbsp;GnRH&nbsp;or any other&nbsp;GnRH&nbsp;&#8211;&nbsp;analogue&nbsp;(medicines similar GONAPEPTYL)<\/li><li>if you are pregnant or breastfeeding.&nbsp;See section &#8220;pregnancy and breastfeeding&#8221;<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before using Gonapeptyl.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression (possibly severe) has been reported in patients taking Gonapeptyl.&nbsp;Tell your doctor if you are taking this medicine and become depressed.<\/li><li>Mood swings have been reported with the use of this medicine.&nbsp;Your doctor will closely monitor you if you develop depression.<\/li><li>Because treatment with this drug in some cases can lead to cerebral hemorrhage (pituitary apoplexy).&nbsp;Contact your doctor immediately if you experience sudden headache, vomiting or visual disturbances.<\/li><li>Because treatment with this drug can lead to a reduction in bone density with the risk of bone damage.<\/li><li>If you have an increased risk of bone density (&nbsp;osteoporosis&nbsp;), tell your doctor before taking this medicine.&nbsp;Risk factors can be:<ul><li>If someone in the immediate family has a reduction in bone density.<\/li><li>If you drink large amounts of alcohol, have an unhealthy diet and \/ or are a heavy smoker.<\/li><li>If you are being treated with other medicines that may affect your bone density.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><em>Tell your doctor if any of the following warnings apply to you or have previously been agreed with you.<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have mild to severe liver disease<\/li><li>if you have an active allergic condition or if you have previously had an easy allergic reaction<\/li><li>if you are administering this medicine yourself.&nbsp;You should be aware of any allergic reactions (&nbsp;itching&nbsp;, rash, fever).&nbsp;(See section 4 \u201cPossible side effects\u201d).<br><em>If you get such reactions after Gonapeptyl&nbsp;injection&nbsp;,&nbsp;talk&nbsp;to a doctor immediately.<\/em><\/li><li>If you get:<ul><li>abdominal pain<\/li><li>swelling in the abdomen<\/li><li>nausea<\/li><li>vomiting<\/li><li>diarrhea<\/li><li>weight gain<\/li><li>difficulty breathing<\/li><li>reduced urination<br><em>Tell your doctor immediately, even if the symptoms develop a few days after the last&nbsp;injection&nbsp;.&nbsp;<\/em>This can be a sign of high activity in the ovaries which can be serious (section 4 \u201cPossible side effects\u201d).&nbsp;If these symptoms get worse, treatment should be stopped and you should receive treatment in hospital.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>During treatment with this medicine, your doctor will normally&nbsp;prescribe&nbsp;<strong>ultrasound<\/strong>&nbsp;and sometimes&nbsp;<strong>blood tests<\/strong>&nbsp;to monitor the results of your treatment.<\/p>\n\n\n\n<p>During treatment for&nbsp;infertility&nbsp;with hormonal drugs such as this, the risk may increase:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ectopic pregnancy (ectopic pregnancy) if you have previously had a disease in the fallopian tube<\/li><li>miscarriage<\/li><li>multiple pregnancies (twins, triplets,&nbsp;<em>etc.<\/em>&nbsp;)<\/li><li>congenital malformations (physical malformations at birth)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Gonapeptyl<\/h2>\n\n\n\n<p><em>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>Do not use this medicine if you are pregnant or breastfeeding.<\/p>\n\n\n\n<p>If there is a possibility that you are pregnant, this should first be investigated and ruled out by your doctor before starting treatment with this medicine.<\/p>\n\n\n\n<p>Do not continue treatment with Gonapeptyl if you find that you are pregnant during treatment.&nbsp;A non-hormonal contraceptive (such as a condom or&nbsp;pessary&nbsp;) should be used during treatment with Gonapeptyl.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine is unlikely to affect your ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Gonapeptyl contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;dose, ie essentially &#8216;sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Gonapeptyl<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Consult a doctor if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is an&nbsp;injection&nbsp;under the skin in the lower abdomen once a day.&nbsp;Treatment can be started on days 2-3 or days 21-23 of the menstrual cycle (or 5-7 days before the expected menstruation).&nbsp;After 2-4 weeks, you will receive other&nbsp;hormones&nbsp;to stimulate follicle growth (egg sac growth).&nbsp;In general, Gonapeptyl treatment is continued until the follicles have reached the appropriate size.&nbsp;This normally takes 4-7 weeks.<\/p>\n\n\n\n<p>When there are enough egg sacs, you will receive a single&nbsp;injection&nbsp;of a drug called&nbsp;human chorionic gonadotropin&nbsp;(&nbsp;hCG&nbsp;) to induce ovulation.<\/p>\n\n\n\n<p>The doctor will closely monitor events in at least 2 weeks after&nbsp;hCG&nbsp;&#8211;&nbsp;injection&nbsp;one.<\/p>\n\n\n\n<p>INSTRUCTIONS FOR USE<\/p>\n\n\n\n<p><em>If the clinic has asked you to inject the medicine yourself, follow the instructions given to them.<\/em><\/p>\n\n\n\n<p>The first&nbsp;injection of&nbsp;one of these medicines should be given under the supervision of a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Remove the protective foil and remove the syringe from the package.&nbsp;Hold the syringe upright with the gray protective sleeve facing up.&nbsp;Remove the gray protective sleeve.&nbsp;Carefully push the plunger in until the first drops are visible in the needle.<\/li><li>Take a grip on the skin between the thumb and forefinger.&nbsp;Push the plunger down and slowly inject the contents of the syringe.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Gonapeptyl than you should&nbsp;<\/h2>\n\n\n\n<p>Tell your doctor or nurse about this.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;If a child has ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Gonapeptyl<\/h2>\n\n\n\n<p>Tell your doctor or nurse about this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Gonapeptyl<\/h2>\n\n\n\n<p>Do not stop using Gonapeptyl yourself, but carefully follow your doctor&#8217;s instructions.&nbsp;If you stop treatment too soon, your chances of getting pregnant will decrease.&nbsp;If you have any further questions on the use of this product, ask your doctor, pharmacist or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effect&nbsp;is<\/strong>&nbsp;(occurring in more than 1 in 10):<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>HeadacheVaginal bleeding \/ intermittent bleedingInflammation&nbsp;at the injection site<\/td><td>Abdominal pain nausea<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Common&nbsp;adverse&nbsp;s<\/strong>&nbsp;(affecting less than 1 in 10):<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>ColdSore throatHot flashesFlatulence in the abdomenMiscarriageOvarian hyperstimulation (high activity), see section 2 \u201cTake special care with Gonapeptyl\u201d.Pain during menstruation fatigue<\/td><td>Flu-like symptomsDizzinessVomitingBack painPelvic painOvarian cysts (at the beginning of treatment)Pain or reactions at the injection site<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(affecting less than 1 in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mood swings, depression<\/li><\/ul>\n\n\n\n<p><strong>No known frequency:<\/strong>&nbsp;Can not be determined from the available data<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Feeling of discomfort in the abdomenHeavy sweatingAllergic reactions (see section 2 \u201cTake special care with Gonapeptyl\u201d)Sleep disordersWeight gainDimsynItchingRashAngioedema&nbsp;(swelling under the skin)WeaknessMuscle cramps<\/td><td>Enlarged ovariesIntermittent bleedingRedness&nbsp;at the injection siteDecreased sex driveRespiratory distressImpaired visionHeavy, prolonged or irregular periodsVaginal drynessPain during intercourseChest painJoint pain<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Gonapeptyl<\/h2>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze.&nbsp;Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is triptorelin acetate.&nbsp;Each pre-filled&nbsp;syringe&nbsp;with 1 ml&nbsp;solution for injection&nbsp;contains 0.1 mg (100 micrograms) of triptorelin acetate corresponding to 95.6 micrograms of triptorelin.<\/li><li>The other ingredients are sodium chloride, concentrated acetic acid and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>This medicine is a clear colorless solution in a 1 ml solid syringe glass syringe.&nbsp;The syringe&nbsp;and needle are sealed with a rubber plug and a needle guard.&nbsp;Gonapeptyl is supplied in a carton of 7 pre-filled syringes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Ferring L\u00e4kemedel AB<\/p>\n\n\n\n<p>Box 4041<\/p>\n\n\n\n<p>203 11 Malm\u00f6<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>Ferring GmbH<\/p>\n\n\n\n<p>PO Box 2145<\/p>\n\n\n\n<p>24109 Kiel<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This medicine is supplied as a syringe in a single-use syringe. It is given as an injection under the skin in the lower abdomen.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14115,14104,14111,14114,14116,14100,14103,14105,14113,14112,14101,14102],"class_list":["post-13685","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-gonapeptyl","tag-benefits-of-triptorelin","tag-gonapeptyl","tag-gonapeptyl-injection","tag-gonapeptyl-side-effects","tag-triptorelin","tag-triptorelin-injection","tag-triptorelin-side-effects","tag-what-gonapeptyl-is-used-for","tag-what-is-gonapeptyl","tag-what-is-triptorelin","tag-what-triptorelin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13685"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13685\/revisions"}],"predecessor-version":[{"id":15395,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13685\/revisions\/15395"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}