{"id":13677,"date":"2021-09-18T16:02:39","date_gmt":"2021-09-18T16:02:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13677"},"modified":"2021-11-03T11:45:28","modified_gmt":"2021-11-03T11:45:28","slug":"glytrin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/glytrin\/","title":{"rendered":"Glytrin &#8211; Glyceryl trinitrate uses, dose and side effects"},"content":{"rendered":"\n<p>0.4 mg\/dose&nbsp;sublingual&nbsp;spray<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/transiderm-nitro\/\">glyceryl trinitrate<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Glytrin is and what it is used for<\/h2>\n\n\n\n<p>Your medicine is called Glytrin.<\/p>\n\n\n\n<p>Glytrin is a&nbsp;sublingual spray&nbsp;(to be used under the tongue) that contains the active substance&nbsp;glyceryl trinitrate.&nbsp;Glyceryl trinitrate&nbsp;belongs to a group of medicines called nitrates.&nbsp;These drugs relax the muscle walls in the blood vessels so that the workload of the heart is reduced.<\/p>\n\n\n\n<p>Glytrin is used to treat&nbsp;acute&nbsp;angina.&nbsp;It is also used to prevent angina caused by physical exertion, emotional stress, cold, etc.<\/p>\n\n\n\n<p>Glyceryl&nbsp;trinitrate contained in Glytrin may also be approved for the treatment of other diseases not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Glytrin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Glytrin and talk to your doctor<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are&nbsp;<strong>allergic<\/strong>&nbsp;to&nbsp;glyceryl trinitrate&nbsp;or other nitrates, or to any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you have very&nbsp;<strong>low&nbsp;blood pressure<\/strong>&nbsp;.<\/li><li>In case of&nbsp;<strong>shock<\/strong>&nbsp;caused by low&nbsp;blood pressure&nbsp;.<\/li><li>If you have severe&nbsp;<strong>anemia<\/strong>&nbsp;(&nbsp;anemia&nbsp;).<\/li><li>If you have&nbsp;<strong>constrictive pericarditis<\/strong>&nbsp;(a type of pericarditis).<\/li><li>If you have a very&nbsp;<strong>low heart rate<\/strong>&nbsp;.<\/li><li>If you have&nbsp;<strong>glucose&nbsp;-6-phosphate dehydrogenase<\/strong>&nbsp;deficiency (a hereditary enzyme deficiency that mainly affects men).<\/li><li>If you have suffered a&nbsp;<strong>brain injury<\/strong>&nbsp;or&nbsp;<strong>cerebral haemorrhage<\/strong>&nbsp;.<\/li><li>If you have&nbsp;<strong>narrowing of the heart valves or&nbsp;arteries&nbsp;are<\/strong>&nbsp;, or chest pain caused by a heart muscle disease.<\/li><li>In case of&nbsp;<strong>circulatory collapse<\/strong>&nbsp;(poor blood circulation).<\/li><li>If you have toxic&nbsp;<strong>pulmonary edema<\/strong>&nbsp;(fluid \/ swelling in the lungs).<\/li><li>In case of&nbsp;<strong>heart shock<\/strong>&nbsp;(a serious condition caused by very low&nbsp;blood pressure&nbsp;and which can lead to dizziness, high&nbsp;heart rate&nbsp;, pallor, sweating, restlessness and unconsciousness).<\/li><\/ul>\n\n\n\n<p>Do not use Glytrin with<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>riociguat<\/strong>&nbsp;for high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs<\/li><li><strong>sildenafil, tildenafil, vardenafil<\/strong>&nbsp;or similar phosphodiesterase inhibitors for&nbsp;erectile dysfunction&nbsp;(&nbsp;impotence&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Glytrin if you have any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fluid in the pericardium (&nbsp;cardiac tamponade&nbsp;)<\/li><li>Low blood flow to the heart (eg&nbsp;acute&nbsp;myocardial infarction)<\/li><li>Problems with&nbsp;blood pressure&nbsp;et<\/li><li>Disease that increases the pressure in the brain<\/li><li>Cataracts&nbsp;(may cause high pressure in the eye)<\/li><li>Liver or kidney problems<\/li><li>Underactive&nbsp;thyroid gland&nbsp;(&nbsp;hypothyroidism&nbsp;, low level of thyroid hormone in the blood)<\/li><\/ul>\n\n\n\n<p>Also, discuss with your doctor if you have had any of these ailments before.&nbsp;You may need to be monitored more closely during the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Glytrin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines.<\/p>\n\n\n\n<p><strong>Do not use Glytrin with<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>riociguat<\/strong>&nbsp;for high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs<\/li><li><strong>sildenafil, tildenafil, vardenafil<\/strong>&nbsp;or similar phosphodiesterase inhibitors for&nbsp;erectile dysfunction&nbsp;(&nbsp;impotence&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Discuss with your doctor before starting treatment with Glytrin if you are taking or have recently taken:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs for the treatment of problems with&nbsp;blood pressure&nbsp;or the heart, such as vasodilators, antihypertensives,&nbsp;beta-blockers&nbsp;,&nbsp;calcium channel&nbsp;blockers&nbsp;.<\/li><li>Tricyclic antidepressant&nbsp;drugs or&nbsp;neuroleptics&nbsp;for mental illness.<\/li><li>Diuretics&nbsp;.<\/li><li>Dihydroergotamine for&nbsp;migraines&nbsp;.<\/li><li>Heparin&nbsp;, a blood thinner to prevent blood clots.&nbsp;Your doctor needs to monitor you more closely.<\/li><li>Organic nitrates&nbsp;(other medicines for&nbsp;acute&nbsp;angina).<\/li><\/ul>\n\n\n\n<p><strong>Glytrin with alcohol<\/strong><\/p>\n\n\n\n<p>Be careful with alcohol intake as the effects of Glytrin may be intensified.&nbsp;Both Glytrin and alcohol can lower&nbsp;blood pressure&nbsp;and impair the&nbsp;ability to react.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.&nbsp;Glytrin should not be used during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Reactivity may be impaired.&nbsp;Therefore, avoid driving or handling machines while taking Glytrin.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Glytrin contains alcohol<\/h2>\n\n\n\n<p>Glytrin contains 7.5 mg of alcohol (&nbsp;ethanol&nbsp;) in each spray.&nbsp;The amount in a spray of this medicine corresponds to less than 1 ml of beer or 1 ml of wine.&nbsp;The low amount of alcohol in this medicine does not produce any noticeable effects.<\/p>\n\n\n\n<p><strong>Prolonged use<\/strong><\/p>\n\n\n\n<p>Prolonged use of Glytrin or other nitrates may lead to impaired treatment effects.&nbsp;Therefore, avoid long-term use with high&nbsp;doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Glytrin<\/h2>\n\n\n\n<ol class=\"wp-block-list\"><li>Glytrin should not be given to children.<\/li><li>Always use this medicine exactly as your doctor and pharmacist have told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/li><li>Learn to use Glytrin before you have an attack as you may need to take Glytrin urgently or in the dark.&nbsp;Familiarize yourself with the spray button that has a finger rest to help you direct the spray jet.<\/li><li>Always have a spare package on hand as it can be difficult to determine how many&nbsp;doses&nbsp;you have left in the container.<\/li><li><strong>Never use Glytrin near open flames, such as glowing cigarettes.<\/strong><\/li><li><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19980306000028#\" rel=\"noopener\"><\/a><strong>Before using Glytrin for the first time<\/strong>&nbsp;, check that the spray works by pressing the pump button a few times until a fine shower of liquid is formed.&nbsp;Practice aiming the spray at a napkin or similar object, so that you can aim it correctly under the tongue when you need to use it.&nbsp;<strong>If you rarely need to use Glytrin<\/strong>&nbsp;, remember to check the spray regularly to make sure it is still working properly.<\/li><li>At the beginning of an attack or to prevent an attack:<ul><li>Sit down<\/li><li>Hold the container upright and close to your mouth<\/li><li><strong>Hold your breath<\/strong><\/li><li>Direct the&nbsp;<strong>spray under the tongue<\/strong><\/li><li>Press the button hard, once<\/li><li><strong>Close your mouth<\/strong>&nbsp;immediately<\/li><li><strong>Do not<\/strong>&nbsp;inhale the spray<\/li><\/ul><\/li><li><strong>The usual&nbsp;dose<\/strong>&nbsp;is one to two&nbsp;doses&nbsp;.&nbsp;More than three&nbsp;doses&nbsp;are not recommended at a time.<\/li><li>Rest for a while after taking Glytrin.&nbsp;Then get up slowly as you may faint.<\/li><\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Glytrin than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<p>Usually, no special treatment is required.<\/p>\n\n\n\n<p>The symptoms of overdose are usually the same as the&nbsp;side effects&nbsp;listed.&nbsp;Some people may experience&nbsp;shock-like reactions, with nausea, lethargy, and sweating.<\/p>\n\n\n\n<p>In rare cases, lips and\/or fingers assume a bluish color (cyanosis or methemoglobinemia).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you experience any of the following serious and rare&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 1000, unless otherwise specified),&nbsp;<strong>must immediately stop taking Glytrin and consult your doctor:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic skin reaction (with or without rash).<\/li><li>Blisters on the tongue (may affect up to 1 in 100 people).<\/li><li>Fainting<\/li><li>Severe drop in blood pressure when you stand up<\/li><li>Exacerbated angina symptoms<\/li><li>Effects on blood circulation (decrease in&nbsp;blood pressure&nbsp;, which may be followed by loss of consciousness and collapse)<\/li><li>Transient&nbsp;hypoxemia&nbsp;(lack of oxygen) (bluish coloration of the lips, hands or feet, which may be followed by loss of consciousness)<\/li><li>Patients with coronary heart disease may have insufficient blood supply to the heart.<\/li><\/ul>\n\n\n\n<p><strong>Continuous&nbsp;use of Glytrin may lead to habituation and reduced treatment effect.&nbsp;If symptoms persist, seek medical advice immediately.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><em>Very common<br>(may affect more than 1 user in 10)<\/em><\/td><td>headache<\/td><\/tr><tr><td><em>Common<br>(may affect up to 1 in 10 people)<\/em><\/td><td>dizziness, dizziness, nausea, flushing, numbness<\/td><\/tr><tr><td><em>Uncommon<br>(may affect up to 1 in 100 people)<\/em><\/td><td>burning sensation, burning sensation<\/td><\/tr><tr><td><em>Rare<br>(may affect up to 1 in 1,000 people)<\/em><\/td><td>sharp drop in blood pressure, altered&nbsp;pulse<\/td><\/tr><tr><td><em>Very rare<br>(may affect up to 1 in 10,000 users)<\/em><\/td><td>scaly or flaky skin<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>If any of the&nbsp;side effects&nbsp;gets serious, or if you notice any&nbsp;side effects&nbsp;not listed in this leaflet, please tell your doctor.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Glytrin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton and label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Do not store above 25 \u00b0 C.&nbsp;Store in a cold place.&nbsp;Do not freeze.<\/li><li>Glytrin is an aerosol spray and contains liquid under pressure.&nbsp;The container must not be exposed to temperatures above 50 \u00b0 C or punctured.&nbsp;This also applies to empty containers.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance in Glytrin is&nbsp;glyceryl trinitrate&nbsp;.&nbsp;Each spray dose contains 0.4 mg of&nbsp;glyceryl trinitrate&nbsp;.<\/li><li>The other ingredients are peppermint oil,&nbsp;ethanol&nbsp;and 1,1,1,2-tetrafluoroethane (&nbsp;propellant&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Glytrin is a colorless spray in a lacquered aluminum aerosol container, with a metering valve and a lid.&nbsp;Each container contains 200&nbsp;doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>Ayrton Saunders (Ireland) Limited<\/p>\n\n\n\n<p>8a Sandyford Business Center<\/p>\n\n\n\n<p>Blackthorn Avenue, Sandyford<\/p>\n\n\n\n<p>Dublin 18<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Pharmaserve (North West) Ltd<\/p>\n\n\n\n<p>9 Arkwright Road<\/p>\n\n\n\n<p>Astmoor Industrial Estate<\/p>\n\n\n\n<p>Runcorn, Cheshire, WA7 1NU<\/p>\n\n\n\n<p>UK<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glytrin is a sublingual spray (to be used under the tongue) that contains the active substance glyceryl trinitrate. Glyceryl trinitrate belongs to a group of medicines called nitrates. These drugs relax the muscle walls in the blood vessels so that the workload of the heart is reduced.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14147,14152,14143,14148,14146,14153,14151,14145,14150,14144,14149],"class_list":["post-13677","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-glyceryl-trinitrate","tag-benefits-of-glytrin","tag-glyceryl-trinitrate","tag-glyceryl-trinitrate-side-effects","tag-glyceryl-trinitrate-spray","tag-glytrin-side-effects","tag-glytrin-spray","tag-what-glyceryl-trinitrate-is-used-for","tag-what-glytrin-is-used-for","tag-what-is-glyceryl-trinitrate","tag-what-is-glytrin"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13677"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13677\/revisions"}],"predecessor-version":[{"id":15399,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13677\/revisions\/15399"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13677"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13677"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}