{"id":13673,"date":"2021-09-18T16:01:19","date_gmt":"2021-09-18T16:01:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13673"},"modified":"2021-11-03T11:45:35","modified_gmt":"2021-11-03T11:45:35","slug":"glypressin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/glypressin\/","title":{"rendered":"Glypressin &#8211; Terlipressin acetate uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg&nbsp;injection&nbsp;solution<br>terlipressin acetate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Glypressin is and what it is used for<\/h2>\n\n\n\n<p>Glypressin&nbsp;solution for injection&nbsp;contains the active substance terlipressin acetate.<\/p>\n\n\n\n<p><strong>Glypressin is used to treat bleeding&nbsp;esophageal varices.<\/strong><\/p>\n\n\n\n<p>Esophageal varices&nbsp;are dilated blood vessels that occur in the esophagus (esophagus) as a complication of liver disease.&nbsp;They can rupture and bleed, which is a serious and life-threatening condition.<\/p>\n\n\n\n<p>When the active ingredient, terlipressin, is injected into the bloodstream, it is broken down and releases a substance called lysine vasopressin.&nbsp;This acts on the walls of the blood vessels and causes them to constrict, thereby impeding blood flow to the affected veins so that bleeding is reduced.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Glypressin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Glypressin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic (hypersensitive) to terlipressin acetate<\/strong>&nbsp;or any of the other ingredients of Glypressin (listed in section 6).<\/li><li>if you are&nbsp;<strong>pregnant<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have&nbsp;<strong>high&nbsp;blood pressure<\/strong><\/li><li>if you suffer from&nbsp;<strong>heart disease<\/strong><\/li><li>in the treatment of&nbsp;<strong>children and elderly<\/strong>&nbsp;patients as experience is limited in these age groups<\/li><li>if you have&nbsp;<strong>septic&nbsp;shock<\/strong>&nbsp;;&nbsp;septic&nbsp;shock&nbsp;is a serious condition that occurs when a severe&nbsp;infection&nbsp;leads to low&nbsp;blood pressure&nbsp;and low blood flow<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor before using Glypressin if any of these apply to you.<\/strong><\/p>\n\n\n\n<p>During treatment with Glypressin,&nbsp;<strong>blood pressure<\/strong>, heart rate,<strong> and fluid balance<\/strong>&nbsp;should be&nbsp;<strong>monitored continuously.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Glypressin<\/h2>\n\n\n\n<p>Tell&nbsp;<strong>your doctor or another healthcare professional if you are taking or have recently taken any other medicines<\/strong>, including&nbsp;<strong>medicines obtained<\/strong>&nbsp;without a prescription.<\/p>\n\n\n\n<p>It is very important that you tell your doctor if you are taking any type of heart medicine (such as propofol or&nbsp;beta-blockers&nbsp;) as these may increase if they are taken at the same time as Glypressin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Glypressin should not be used during pregnancy.<\/p>\n\n\n\n<p>Glypressin should not be used during breastfeeding as it is unknown whether Glypressin passes into breast milk.<\/p>\n\n\n\n<p>Consult a doctor or healthcare professional before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Not relevant.&nbsp;Glypressin is only used in hospitals.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Glypressin contains sodium<\/h2>\n\n\n\n<p>This medicine contains 1.33 mmol (30.7 mg)&nbsp;sodium&nbsp;per&nbsp;ampoule&nbsp;.&nbsp;Tell your doctor if you are on a low-salt diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Glypressin<\/h2>\n\n\n\n<p>Glypressin is a medicine used in hospitals, and should only be given by qualified personnel.<\/p>\n\n\n\n<p>The solution is injected&nbsp;intravenously&nbsp;(directly into the bloodstream).<\/p>\n\n\n\n<p>The usual starting dose of Glypressin for sudden bleeding from&nbsp;esophageal varices&nbsp;is 2 mg.&nbsp;The additional&nbsp;dose&nbsp;is usually 1-2 mg every four hours until the bleeding has been under control for 24 hours.&nbsp;Treatment should not last more than 48 hours.<\/p>\n\n\n\n<p>After starting dose can&nbsp;be dose-adjusted relative to body weight or any&nbsp;side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><strong>Common (affects 1 to 10 users in 100):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Bradycardia&nbsp;(very low heart rate)<\/li><li>Contraction of blood vessels (insufficient blood flow to&nbsp;tissue&nbsp;) leading to pallor<\/li><li>High&nbsp;blood pressure<\/li><li>Transient abdominal pain<\/li><li>Transient diarrhea<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (affects 1-10 users in 1000):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low sodium in blood if fluid is not monitored<\/li><li>Uneven heart rate<\/li><li>Increased&nbsp;heart rate<\/li><li>Chest pain<\/li><li>Myocardial infarction&nbsp;(heart attack)<\/li><li>Pulmonary edema<\/li><li>Torsade de pointes&nbsp;(&nbsp;cardiac arrhythmia&nbsp;)<\/li><li>Heart failure&nbsp;, symptoms are shortness of breath, fatigue and swollen ankles<\/li><li>Insufficient blood flow to the intestines<\/li><li>Peripheral&nbsp;cyanosis (bluish skin color due to low oxygen content in the blood)<\/li><li>Hot flashes<\/li><li>Shortness of breath and&nbsp;insufficiency&nbsp;(difficulty breathing)<\/li><li>Transient nausea<\/li><li>Transient vomiting<\/li><li>Skin necrosis (tissue damage)<\/li><li>Uterine contractions<\/li><li>Reduced blood flow through the uterus<\/li><\/ul>\n\n\n\n<p><strong>Rare (affects 1-10 of 10,000 users)<\/strong><\/p>\n\n\n\n<p>&#8211; Dyspnoea (difficulty breathing)<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency,&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Glypressin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).&nbsp;Store the&nbsp;ampoules in&nbsp;their original packaging.&nbsp;Sensitive to light.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>One&nbsp;ampoule&nbsp;of 8.5 ml contains 1 mg terlipressin acetate, equivalent to 0.85 mg terlipressin as an active substance.<\/p>\n\n\n\n<p>1 ml solution contains 0.12 mg terlipressin acetate as an active substance.<\/p>\n\n\n\n<p>The other ingredients are sodium chloride, acetic acid, sodium acetate trihydrate, water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>The product is a clear colorless solution for&nbsp;injection.<\/p>\n\n\n\n<p>Glypressin is supplied in a pack size:<\/p>\n\n\n\n<p>5&nbsp;ampoules&nbsp;are 8.5 ml.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>Ferring L\u00e4kemedel AB<\/p>\n\n\n\n<p>Box 4041<\/p>\n\n\n\n<p>203 11 Malm\u00f6<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Ferring-L\u00e9\u010diva as<\/p>\n\n\n\n<p>K Rybn\u00edku 475<\/p>\n\n\n\n<p>252 42 Jesenice near Prague<\/p>\n\n\n\n<p>Czech Republic<\/p>\n\n\n\n<p>Ferring GmbH<\/p>\n\n\n\n<p>Wittland 11<\/p>\n\n\n\n<p>D-24109 Kiel<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glypressin solution for injection contains the active substance terlipressin acetate.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14158,13703,14160,14163,14164,14154,14157,14159,14162,14161,14155,14156],"class_list":["post-13673","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-terlipressin-acetate","tag-benefits-of-v","tag-glypressin","tag-glypressin-injection","tag-glypressin-side-effects","tag-terlipressin-acetate","tag-terlipressin-acetate-injection","tag-terlipressin-acetate-side-effects","tag-what-glypressin-is-used-for","tag-what-is-glypressin","tag-what-is-terlipressin-acetate","tag-what-terlipressin-acetate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13673"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13673\/revisions"}],"predecessor-version":[{"id":15400,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13673\/revisions\/15400"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}