{"id":13448,"date":"2021-09-17T11:37:39","date_gmt":"2021-09-17T11:37:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13448"},"modified":"2021-11-05T11:57:14","modified_gmt":"2021-11-05T11:57:14","slug":"glucagon-novo-nordisk","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/glucagon-novo-nordisk\/","title":{"rendered":"Glucagon Novo Nordis &#8211; Glucagon uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg of&nbsp;powder and solvent for&nbsp;injection, solution<br>Glucagon<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Glucagon Novo Nordisk is and what it is used for<\/h2>\n\n\n\n<p>Glucagon&nbsp;Novo Nordisk contains the active substance glucagon.<\/p>\n\n\n\n<p>Glucagon&nbsp;Novo Nordisk is intended for immediate use in acute cases in children and adults with&nbsp;diabetes&nbsp;using&nbsp;insulin.&nbsp;It is used for unconsciousness due to very low blood sugar.&nbsp;This is called &#8220;severe hypoglycaemia&#8221;.&nbsp;Glucagon&nbsp;Novo Nordisk is used when the person cannot ingest sugar by mouth.<\/p>\n\n\n\n<p>Glucagon is a natural&nbsp;hormone, which has the opposite effect to&nbsp;insulin&nbsp;in the body.&nbsp;It helps the liver convert a substance called &#8220;glycogen&#8221; into&nbsp;glucose&nbsp;(sugar).&nbsp;Glucose&nbsp;is then released into the bloodstream &#8211; this raises blood sugar levels.<\/p>\n\n\n\n<p><strong>For doctors \/ nurses:<\/strong>&nbsp;See section 7.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Glucagon Novo Nordisk<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Important information<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Make sure your family members, co-workers or close friends know about&nbsp;Glucagon&nbsp;Novo Nordisk.&nbsp;Tell them that if you become unconscious, they should use&nbsp;Glucagon&nbsp;Novo Nordisk immediately.<\/li><li>Show your family members and others where to store&nbsp;Glucagon&nbsp;Novo Nordisk and how to use it.&nbsp;They need to act fast &#8211; if you are unconscious for a while it can be harmful.&nbsp;It is important that they have received instructions and know how to&nbsp;use Glucagon&nbsp;Novo Nordisk before you need it.<\/li><li>Prepare a solution of&nbsp;Glucagon&nbsp;Novo Nordisk powder (compact powder cake) and&nbsp;diluent&nbsp;before&nbsp;injection&nbsp;.&nbsp;Tell your family members and others to follow the instructions in section 3: How to use&nbsp;Glucagon&nbsp;Novo Nordisk.<\/li><li>Any unused&nbsp;solution of&nbsp;Glucagon&nbsp;Novo Nordisk must be discarded.<\/li><li>After receiving&nbsp;Glucagon&nbsp;Novo Nordisk, you or someone else must contact your doctor or healthcare professional.&nbsp;You need to know the reason for your very low blood sugar and how you can prevent it from happening again.<\/li><\/ul>\n\n\n\n<p><strong>Do not&nbsp;use Glucagon&nbsp;Novo Nordisk if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to glucagon or any of the other ingredients of this medicine (listed in section 6).<\/li><li>you have a&nbsp;tumor&nbsp;in your&nbsp;adrenal gland&nbsp;.<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, do not&nbsp;use Glucagon&nbsp;Novo Nordisk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using&nbsp;Glucagon&nbsp;Novo Nordisk.<\/p>\n\n\n\n<p><strong>Glucagon&nbsp;Novo Nordisk does not operate as intended if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have been fasting for a long time<\/li><li>you have low levels of&nbsp;adrenaline<\/li><li>Your low blood sugar is due to consuming too much alcohol<\/li><li>you have a&nbsp;tumor&nbsp;that secretes glucagon or&nbsp;insulin<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Glucagon Novo Nordisk<\/h2>\n\n\n\n<p>The following medicines may affect the effect of&nbsp;Glucagon&nbsp;Novo Nordisk:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>insulin&nbsp;&#8211; used to treat&nbsp;diabetes&nbsp;.<\/li><li>indomethacin &#8211; used to treat joint pain and stiffness.<\/li><\/ul>\n\n\n\n<p>The effect of the following medicines may be affected by&nbsp;Glucagon&nbsp;Novo Nordisk:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>warfarin&nbsp;&#8211; used to treat blood clots.&nbsp;Glucagon&nbsp;Novo Nordisk may increase the blood-thinning effect of&nbsp;warfarin&nbsp;.<\/li><li>beta-receptor blockers &#8211; used to treat high&nbsp;blood pressure&nbsp;and irregular heartbeat.&nbsp;Glucagon&nbsp;Novo Nordisk can increase&nbsp;blood pressure&nbsp;and&nbsp;heart rate&nbsp;, but this only lasts a short time.<\/li><\/ul>\n\n\n\n<p>If any of these apply to you (or you are not&nbsp;sure&nbsp;), talk to your doctor or pharmacist before&nbsp;taking Glucagon&nbsp;Novo Nordisk.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you experience very low blood sugar when you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, you can use&nbsp;Glucagon&nbsp;Novo Nordisk.<\/p>\n\n\n\n<p>If you are pregnant, ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you still feel the effects of severe&nbsp;hypoglycaemia&nbsp;, do not drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Glucagon Novo Nordisk contains sodium<\/h2>\n\n\n\n<p>Glucagon&nbsp;Novo Nordisk contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per maximum&nbsp;dose&nbsp;(2 ml), ie&nbsp;essentially &#8216;sodium-free.&nbsp;is next to &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Glucagon Novo Nordisk<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;If you are not sure, ask your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Preparation&nbsp;of solution and&nbsp;injection<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19670622000016#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/2c71cfb4-541c-4714-a6e5-4b890dafa199\" alt=\"Draw up all the water in a disposable syringe.  Insert the injection needle through the rubber membrane (within the marked circle) into the glucagon vial and inject all the water from the syringe into the vial.\" title=\"Draw up all the water in a disposable syringe.  Insert the injection needle through the rubber membrane (within the marked circle) into the glucagon vial and inject all the water from the syringe into the vial.\"\/><\/a><\/figure>\n\n\n\n<p>1. Remove both plastic caps from the vials.&nbsp;Draw up all the water in a disposable syringe.&nbsp;Insert the injection needle through the rubber membrane (within the marked circle) into the glucagon vial and&nbsp;inject&nbsp;all the water from the syringe into the vial.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19670622000016#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/8a085773-af3d-48c8-8282-d203f2bdcbfb\" alt=\"Leave the injection needle in place and shake the vial gently until all the glucagon powder has dissolved and a clear solution has been obtained.\" title=\"Leave the injection needle in place and shake the vial gently until all the glucagon powder has dissolved and a clear solution has been obtained.\"\/><\/a><\/figure>\n\n\n\n<p>2. Leave the injection needle in place and shake the vial gently until all the glucagon powder has dissolved and a clear solution has been obtained.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19670622000016#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/ae5b81dc-b35e-4808-89e2-a684d26c9091\" alt=\"Hold the injection needle in the liquid and slowly withdraw all the solution to the syringe. \" title=\"Hold the injection needle in the liquid and slowly withdraw all the solution to the syringe. \"\/><\/a><\/figure>\n\n\n\n<p>3. Check that the rubber piston is fully depressed.&nbsp;Hold the injection needle in the liquid and slowly withdraw all the solution to the syringe.&nbsp;Do not pull the rubber plunger out of the syringe.&nbsp;It is important to remove any air bubbles in the syringe by:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>with the injection needle pointing upwards, tap the syringe with one finger<\/li><li>gently push in the plunger to&nbsp;spray&nbsp;the air collected at the top of the syringe.<\/li><\/ul>\n\n\n\n<p>Continue to push the plunger in until you have set the correct&nbsp;dose&nbsp;for&nbsp;injection.&nbsp;A small amount of liquid will drain out when you do this.<\/p>\n\n\n\n<p>See&nbsp;<em>How much should I use<\/em>&nbsp;below.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19670622000016#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/afb54c5e-4953-4a1e-9a8c-6a7603a2d6e9\" alt=\"Inject the dose under the skin (subcutaneously) or into muscle.\" title=\"Inject the dose under the skin (subcutaneously) or into muscle.\"\/><\/a><\/figure>\n\n\n\n<p>Inject&nbsp;dose&nbsp;one under the skin (&nbsp;subcutaneously&nbsp;) or into muscle.<\/p>\n\n\n\n<p>5. Turn the unconscious person on their side to prevent suffocation.<\/p>\n\n\n\n<p>Give the person something high in sugar such as sweets, biscuits, or fruit juices as soon as he or she regains consciousness and can eat.&nbsp;Snacks with a high sugar content prevent the blood sugar from falling again.<\/p>\n\n\n\n<p>After receiving&nbsp;Glucagon&nbsp;Novo Nordisk, you or someone else must contact your doctor or healthcare provider.&nbsp;You need to know the reason for your very low blood sugar and how you can prevent it from happening again.<\/p>\n\n\n\n<p><strong>How much should I use?<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Adults:<\/strong>&nbsp;inject the full amount of medicine (1 ml).<\/li><li><strong>Children under 8 years or children over 8 years weighing less than 25 kg:<\/strong>&nbsp;inject half the amount of medicine (0.5 ml).<\/li><li><strong>Children over 8 years of age or children under 8 years of age weighing more than 25 kg:<\/strong>&nbsp;inject the full amount of medicine (1 ml).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Glucagon Novo Nordisk than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has ingested the medicine by mistake, always contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.&nbsp;If you take too high a&nbsp;dose&nbsp;of&nbsp;Glucagon&nbsp;Novo Nordisk, it may cause severe vomiting.&nbsp;No special treatment is usually necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may occur with this medicine:<\/p>\n\n\n\n<p><strong>Contact a doctor immediately if you notice any of the following side effects:<\/strong><\/p>\n\n\n\n<p><strong>Very rare:<\/strong>&nbsp;may affect up to 1 in 10,000 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction&nbsp;&#8211; signs of this may include wheezing, sweating, palpitations, rash, swelling of the face and collapse.<\/li><li><strong>Contact a doctor immediately<\/strong>&nbsp;if you notice any of the&nbsp;side effects&nbsp;listed above.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Vomiting.<\/li><\/ul>\n\n\n\n<p><strong>Rare:<\/strong>&nbsp;may affect up to 1 in 1,000 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abdominal pain.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Glucagon Novo Nordisk<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Store&nbsp;<strong>in a refrigerator<\/strong>&nbsp;(2 \u00b0 C &#8211; 8 \u00b0 C).<\/li><li>Store in the original package.&nbsp;Sensitive to light.<\/li><li>Do not freeze to avoid damage to the product.<\/li><li>Used immediately after&nbsp;preparation&nbsp;&#8211; not saved for later use.<\/li><li>Do not use this medicine after the expiry date which is stated on the label after \u201cEXP\u201d.&nbsp;Expiration date is the last day of the specified month.<\/li><li>Do not use the reconstituted solution if it has become jelly-like or if the powder is not completely dissolved.<\/li><li>Do not use the package if the plastic caps have come loose or are missing when you receive them &#8211; return the package to the pharmacy.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is glucagon 1 mg as hydrochloride, produced in yeast by&nbsp;recombinant&nbsp;&#8211;&nbsp;DNA&nbsp;technology.<\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;, water for injections,&nbsp;hydrochloric acid&nbsp;and \/ or sodium hydroxide (for&nbsp;pH&nbsp;adjustment&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Glucagon&nbsp;Novo Nordisk consists of a sterile, white glucagon powder in a&nbsp;vial&nbsp;and&nbsp;diluent&nbsp;in a&nbsp;vial.&nbsp;The powder is in the form of a compact powder cake.&nbsp;The reconstituted solution contains glucagon 1 mg\/ml.<\/p>\n\n\n\n<p>Pack sizes: 1 x 1 mg and 10 x 1 mg.&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Novo Nordisk A \/ S<\/p>\n\n\n\n<p>Novo All\u00e9<\/p>\n\n\n\n<p>DK-2880 Bagsv\u00e6rd, Denmark<\/p>\n\n\n\n<p><strong>7. Additional information for healthcare professionals<\/strong><\/p>\n\n\n\n<p>Medical personnel is referred to all previous sections before reading the additional information below.<\/p>\n\n\n\n<p><strong>Due&nbsp;to the&nbsp;unstable solution of Glucagon&nbsp;Novo Nordisk, it should be given immediately after&nbsp;reconstitution&nbsp;and should not be given as an&nbsp;intravenous&nbsp;infusion&nbsp;.<\/strong><\/p>\n\n\n\n<p><strong>Treatment of severe&nbsp;hypoglycaemia<\/strong><\/p>\n\n\n\n<p>Administered as a&nbsp;subcutaneous&nbsp;or&nbsp;intramuscular&nbsp;injection.&nbsp;If the patient does not respond to treatment within 10 minutes,&nbsp;glucose&nbsp;is given&nbsp;intravenously.&nbsp;When the patient responds to the treatment, carbohydrates are given orally, to restore liver&nbsp;glycogen&nbsp;and prevent recurrence of&nbsp;hypoglycemia&nbsp;.<\/p>\n\n\n\n<p><strong>Use in diagnostics<\/strong><\/p>\n\n\n\n<p>When the examination is completed, carbohydrates should be given orally, if this is consistent with the current diagnostic examination.&nbsp;Remember that&nbsp;Glucagon&nbsp;Novo Nordisk has the opposite effect to&nbsp;insulin.&nbsp;Caution should be&nbsp;exercised&nbsp;when&nbsp;using Glucagon&nbsp;Novo Nordisk as an aid in&nbsp;endoscopy&nbsp;or radiological examination of patients with&nbsp;diabetes&nbsp;or elderly patients with heart disease.<\/p>\n\n\n\n<p>Examination of the gastrointestinal tract:<\/p>\n\n\n\n<p>Dosage&nbsp;one varies between 0.2\u20132 mg depending on the examination technique and route of administration.&nbsp;The diagnostic&nbsp;dose&nbsp;for&nbsp;ventricular,&nbsp;duodenal&nbsp;bulbus,&nbsp;duodenum&nbsp;and small bowel&nbsp;relaxation&nbsp;is 0.2\u20130.5 mg&nbsp;intravenously&nbsp;or 1 mg&nbsp;intramuscularly&nbsp;.&nbsp;The dose&nbsp;for colon relaxation is 0.5-0.75 mg&nbsp;intravenously&nbsp;or 1-2 mg&nbsp;intramuscularly.&nbsp;After an&nbsp;intravenous&nbsp;injection&nbsp;of 0.2-0.5 mg, the effect sets in within one minute and lasts 5-20 minutes.&nbsp;After an&nbsp;intramuscular&nbsp;injection&nbsp;of 1-2 mg, the effect sets in after 5\u201315 minutes and lasts approximately 10\u201340 minutes.<\/p>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;are when used in diagnostics<\/strong><\/p>\n\n\n\n<p>Changes in blood pressure,&nbsp;tachycardia,&nbsp;hypoglycaemia,&nbsp;and hypoglycaemic&nbsp;coma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glucagon Novo Nordisk contains the active substance glucagon.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14336,14340,9305,14337,14341,9307,9308,14339,9306,14338],"class_list":["post-13448","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-glucagon","tag-benefits-of-glucagon-novo-nordis","tag-glucagon","tag-glucagon-novo-nordis","tag-glucagon-novo-nordis-side-effects","tag-glucagon-side-effects","tag-what-glucagon-is-used-for","tag-what-glucagon-novo-nordis-is-used-for","tag-what-is-glucagon","tag-what-is-glucagon-novo-nordis"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13448"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13448\/revisions"}],"predecessor-version":[{"id":15471,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13448\/revisions\/15471"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}