{"id":13426,"date":"2021-09-16T07:43:09","date_gmt":"2021-09-16T07:43:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13426"},"modified":"2021-11-06T11:32:54","modified_gmt":"2021-11-06T11:32:54","slug":"glibenclamide-recip","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/glibenclamide-recip\/","title":{"rendered":"Glibenclamide Recip &#8211; Glibenclamide uses, dose and side effects"},"content":{"rendered":"\n<p>1.75 mg, 3.5 mg&nbsp;tablets<br>glibenclamide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Glibenclamide Recip is and what it is used for<\/h2>\n\n\n\n<p>Glibenclamide Recip has blood sugar lowering effect by increasing the pancreas&#8217; own insulin production and possibly making this&nbsp;insulin&nbsp;more effective.<\/p>\n\n\n\n<p>Glibenclamide is used in adult-onset diabetes (Type II &#8211;&nbsp;diabetes mellitus&nbsp;) where diet alone, weight reduction, and exercise alone do not provide sufficient effect.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Glibenclamide Recip<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use glibenclamide:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to glibenclamide or any of the other ingredients of Glibenclamide Recip.<\/li><li>if you have&nbsp;type 1&nbsp;diabetes mellitus&nbsp;(insulin-dependent&nbsp;diabetes&nbsp;).<\/li><li>in diabetic coma and in case of too high content of acidic substances in the body (&nbsp;ketoacidosis&nbsp;).<\/li><li>in case of malnutrition.<\/li><li>in severe renal or hepatic impairment.<\/li><li>in acute conditions that complicate the diabetes disease, such as&nbsp;infection&nbsp;or cold sores.<\/li><li>when co-administered with medicines containing&nbsp;bosentan&nbsp;(used to treat high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Glibenklamide Recip.<\/p>\n\n\n\n<p>Blood sugar should be checked regularly.<\/p>\n\n\n\n<p>The risk of low blood sugar (hypoglycemia) is increased during the first weeks of treatment.<\/p>\n\n\n\n<p>With impaired kidney or liver function and after prolonged fasting, the blood sugar lowering effect may become too strong.<\/p>\n\n\n\n<p><em>Hypoglycaemia&nbsp;(&nbsp;hypoglycaemia&nbsp;)<\/em><\/p>\n\n\n\n<p>Hypoglycaemia&nbsp;(&nbsp;hypoglycaemia&nbsp;), a so-called &#8220;feeling&#8221;, can occur with the concomitant use of other drugs, overdose, irregular meals, decreased food or fluid intake, stress, and increased physical activity.<\/p>\n\n\n\n<p>Mild symptoms of low blood sugar can range from hunger, lethargy, drowsiness, visual disturbances, irritability, emotional disturbances, confusion, sweating, anxiety, tremors, coordination problems, pallor, and headaches.&nbsp;In most cases, the symptoms disappear fairly quickly after consuming sugar.&nbsp;You should therefore always carry some form of sugar with you, such as grape sugar, chocolate, or the like.&nbsp;Note that sweeteners have no effect.&nbsp;If sugar intake does not help or if symptoms return, contact your doctor or hospital.&nbsp;More serious symptoms of low blood sugar can be seizures and if the blood sugar does not rise, unconsciousness can occur.&nbsp;Doctors should be contacted immediately in case of more severe symptoms.<\/p>\n\n\n\n<p>In case of severe overdose, there is a risk of affecting the brain, heart, blood, liver, and respiration.<\/p>\n\n\n\n<p><em>Elevated blood sugar (&nbsp;hyperglycaemia&nbsp;)<\/em><\/p>\n\n\n\n<p>Signs of high blood sugar (&nbsp;hyperglycaemia&nbsp;) may include thirst, frequent urination,&nbsp;dry mouth,&nbsp;and dry skin.&nbsp;In such cases, a doctor should be consulted.&nbsp;In connection with accidents, operations, and febrile conditions, it may be necessary to switch to insulin treatment.<\/p>\n\n\n\n<p>People who are hypersensitive to other medicines in the same group (sulphonylureas and&nbsp;sulphonamides&nbsp;) may also develop allergic reactions to Glibenclamide Recip.<\/p>\n\n\n\n<p>Glibenclamide Recip can in rare cases affect the white&nbsp;blood cells&nbsp;so that the defense of infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general condition or fever with local infection symptoms such as sore throat\/pharynx\/mouth or urination problems, you should see a doctor as soon as possible so that blood tests can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;).&nbsp;It is important that you then inform about your medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Glibenclamide Recip<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>The following combination with glibenclamide should not be used.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for the treatment of high&nbsp;blood pressure&nbsp;in the lungs (&nbsp;bosentan&nbsp;)<\/li><\/ul>\n\n\n\n<p>The following medicines may increase the blood-glucose-lowering effect of Glibenclamide, which may lead to an increased risk of&nbsp;hypoglycemia&nbsp;(low blood sugar).<\/p>\n\n\n\n<p>Drug:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>used in diabetes treatment (such as&nbsp;insulin&nbsp;, or&nbsp;metformin&nbsp;)<\/li><li>in the treatment of pain and&nbsp;inflammation&nbsp;(phenylbutazone, azapropazone and oxyfenbutazone)<\/li><li>that promotes muscle building (anabolic&nbsp;steroids&nbsp;)<\/li><li>used in the replacement of male sex hormone<\/li><li>in the treatment of depression (&nbsp;fluoxetine&nbsp;,&nbsp;MAO inhibitors&nbsp;)<\/li><li>in the treatment of&nbsp;tuberculosis&nbsp;(para-aminosalicylic acid)<\/li><li>used primarily in the treatment of&nbsp;infection&nbsp;your urinary tract and&nbsp;prostate&nbsp;(+ sulfamethoxazole trimethoprim)<\/li><li>which lowers high&nbsp;blood pressure&nbsp;or is used in the treatment of certain heart diseases (&nbsp;ACE inhibitors&nbsp;)<\/li><li>that lowers high cholesterol levels (fibrates)<\/li><li>in the treatment of cancer (cyclophosphamide and ifosphosamide)<\/li><li>in the treatment of&nbsp;gout&nbsp;(probenecid and sulfinpyrazone)<\/li><li>in the treatment of nasal&nbsp;allergies&nbsp;such as hay fever (tritoqualin)<\/li><li>which increase blood circulation when given in high&nbsp;doses&nbsp;by&nbsp;intravenous&nbsp;infusion&nbsp;(pentoxifylline)<\/li><li>used for weight loss (fenfluramine)<\/li><li>called sympatholytic drugs such as&nbsp;beta-blockers&nbsp;and guanetidine used to treat high&nbsp;blood pressure&nbsp;,&nbsp;heart failure&nbsp;or prostate symptoms<\/li><li>used in the treatment of&nbsp;bacterial&nbsp;and fungal infections (&nbsp;tetracyclines&nbsp;, chloramphenicol,&nbsp;fluconazole&nbsp;,&nbsp;miconazole&nbsp;, quinelone antibiotics, clarithromycin)<\/li><li>Salicylic acid derivatives (used to remove dry and scaly skin, eg in&nbsp;psoriasis&nbsp;),<\/li><\/ul>\n\n\n\n<p>The following medicines may lower the blood sugar lowering effect of Glibenclamide.&nbsp;This may lead to an increased risk of&nbsp;hyperglycaemia&nbsp;(high blood sugar):<\/p>\n\n\n\n<p>Drug:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>containing female sex hormones (&nbsp;estrogens&nbsp;, progestogens)<\/li><li>in the treatment of increased pressure in the eye (acetazolamide)<\/li><li>in the treatment of anxiety and sleep problems (&nbsp;barbiturates&nbsp;)<\/li><li>diuretic&nbsp;(&nbsp;diuretic&nbsp;)<\/li><li>which stimulates the thyroid gland (such as levothyroxine)<\/li><li>in the treatment of seizures (&nbsp;phenytoin&nbsp;)<\/li><li>in the treatment of&nbsp;allergies&nbsp;and&nbsp;inflammation&nbsp;(&nbsp;glucocorticoids&nbsp;)<\/li><li>in the treatment of severe mental disorder (phentiazine derivatives)<\/li><li>in the treatment of high cholesterol levels (&nbsp;nicotinic acid&nbsp;)<\/li><li>for long-term treatment of constipation (&nbsp;laxatives&nbsp;)<\/li><li>in the treatment of high&nbsp;blood pressure&nbsp;or in the treatment of low blood sugar (diazoxide)<\/li><li>in the treatment of severe hypoglycaemia (glucagon)<\/li><li>used in life-threatening situations (&nbsp;sympathomimetic&nbsp;)<\/li><li>in the treatment of&nbsp;infection&nbsp;,&nbsp;tuberculosis&nbsp;(rifampicin)<\/li><\/ul>\n\n\n\n<p>The following medicines may either enhance or weaken the blood-glucose-lowering effect of Glibenclamide:<\/p>\n\n\n\n<p>Drug:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in the treatment of&nbsp;gastric ulcers&nbsp;(so-called H2&nbsp;antagonists&nbsp;)<\/li><li>in the treatment of high&nbsp;blood pressure&nbsp;or&nbsp;heart failure&nbsp;such as&nbsp;beta-blockers&nbsp;,&nbsp;clonidine&nbsp;and reserpine.&nbsp;These medicines can also hide the signs of&nbsp;hypoglycaemia&nbsp;, so special precautions should be taken when using them.<\/li><\/ul>\n\n\n\n<p>The following medicines may be affected by glibenclamide<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cimetidine (used to treat&nbsp;stomach ulcers&nbsp;)<\/li><\/ul>\n\n\n\n<p>Glibenclamide may either potentiate or attenuate the effects of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs that inhibit blood coagulation (coumarin derivatives such as&nbsp;warfarin&nbsp;)<\/li><li>Ciclosporin (used to block the body&#8217;s natural immune system)<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>The effect of glibenclamide may be affected if glibenclamide and alcohol are taken at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>There is a risk that the fetus is affected.&nbsp;Glibenclamide should therefore not be used during pregnancy but should be replaced by&nbsp;insulin.&nbsp;If you are planning to become pregnant, tell your doctor.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>It is not known if glibenclamide passes into breast milk but other drugs in the same group (sulphonylureas) do.&nbsp;Glibenclamide should therefore not be used during breastfeeding.&nbsp;Consult a doctor as it may be necessary to switch to&nbsp;insulin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>When treated with Glibenclamide Recip, in some cases you can get too low blood sugar (&nbsp;hypoglycemia&nbsp;), which results in a reduced&nbsp;ability to react.&nbsp;At the beginning of treatment, a transient visual impairment may occur due to the change in blood sugar level.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Glibenclamide Recip contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Glibenclamide Recip<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<p>Dose&nbsp;one is determined by your doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p>Usually, Glibenclamide recip dosed as a single dose before breakfast target but at higher daily doses maybe sometimes a&nbsp;dose&nbsp;given before breakfast and a target&nbsp;dose&nbsp;before the evening meal (supper).<\/p>\n\n\n\n<p>The tablets should always be taken just before or at mealtime.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Glibenclamide Recip than you should&nbsp;<\/h2>\n\n\n\n<p>If you have taken too large a&nbsp;dose&nbsp;of the medicine or if, for example, a child has ingested the medicine by mistake, always contact a doctor, a hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<p>Symptoms of overdose include low blood sugar, nausea, vomiting, abdominal pain, anxiety, tremors, visual disturbances, coordination problems, drowsiness, unconsciousness (&nbsp;coma&nbsp;) and seizures.<\/p>\n\n\n\n<p>If overdose is suspected, sugar, fruit juice, or similar should be taken immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Glibenclamide Recip<\/h2>\n\n\n\n<p>DO NOT take a double&nbsp;dose&nbsp;to make up for a&nbsp;forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Glibenclamide Recip<\/h2>\n\n\n\n<p>Modification or termination of treatment should only be done in consultation with a physician.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Glibenclamide Recip can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;that can occur are:<\/p>\n\n\n\n<p><em>Common (affects less than 1 user in 10)<\/em><\/p>\n\n\n\n<p>Nausea, vomiting.<\/p>\n\n\n\n<p><em>Uncommon (affects less than 1 user in 100)<\/em><\/p>\n\n\n\n<p>Low blood sugar (&nbsp;hypoglycaemia&nbsp;), sometimes prolonged and even life-threatening.&nbsp;Skin rash, hives.<\/p>\n\n\n\n<p><em>Rare (affects less than 1 user in 1,000):<\/em><\/p>\n\n\n\n<p>Elevated liver values, impaired liver function, or jaundice.&nbsp;Increased sensitivity to sunlight.&nbsp;Allergic vasculitis can be life-threatening.&nbsp;Hematological changes such as&nbsp;agranulocytosis&nbsp;and&nbsp;thrombocytopenia&nbsp;(see Take special care with Glibenclamide Recip).<\/p>\n\n\n\n<p>Mild forms of hives have in some cases developed into more serious and even life-threatening conditions with respiratory arrest and drop in blood pressure.&nbsp;In case of hives, a doctor should therefore be contacted immediately.<\/p>\n\n\n\n<p>Isolated cases of pressure or satiety, abdominal pain, and diarrhea have been reported.&nbsp;These symptoms often subside with continued use, which rarely makes it necessary to discontinue treatment.<\/p>\n\n\n\n<p>Hepatic impairment has been reported in isolated patients treated with glibenclamide.&nbsp;Conditions that can lead to life-threatening liver failure may return when glibenclamide treatment is stopped.<\/p>\n\n\n\n<p>Transient visual disturbances may occur especially at the beginning of treatment due to changes in blood sugar levels.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Glibenklamide Recip<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Used before the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Empty packaging can be recycled via the Packaging Collection.&nbsp;The jar and lid are sorted as hard plastic packaging.&nbsp;Impression cards and single-dose packaging are sorted as soft plastic packaging.<\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask at the pharmacy how to deal with medicines that are no longer used.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is glibenclamide.&nbsp;One tablet contains 1.75 mg and 3.5 mg respectively.<\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;17.5 mg and 35 mg respectively, maize starch, povidone and magnesium stearate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Glibenclamide Recip 1.75 mg: white with break notch, diameter 6 mm, marked &#8220;GL&#8221;<\/p>\n\n\n\n<p>Glibenclamide Recip 3.5 mg: white with a cut notch, diameter 7.5 mm, marked &#8220;GB&#8221;<\/p>\n\n\n\n<p><strong>Packaging<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>1.75 mg:<\/td><td>49 \u00d7 1 single-dose pack100 pcs pressure packaging100 pcs and 250 pcs in a plastic jar<\/td><\/tr><tr><td>3.5 mg:<\/td><td>49 \u00d7 1 single-dose pack100 pcs pressure packaging100 pcs and 250 pcs print packaging<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder<\/h2>\n\n\n\n<p>RPH Pharmaceuticals AB<\/p>\n\n\n\n<p>Box 603<\/p>\n\n\n\n<p>101 32 Stockholm<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Recipharm Stockholm AB<\/p>\n\n\n\n<p>Lagerv\u00e4gen 7<\/p>\n\n\n\n<p>136 50 Jordbro<\/p>\n\n\n\n<p><strong>Local representative<\/strong><\/p>\n\n\n\n<p>Astimex Pharma AB<\/p>\n\n\n\n<p>Isafjordsgatan 36<\/p>\n\n\n\n<p>164 40 Kista<\/p>\n\n\n\n<p>Tel.&nbsp;08-5151 1535<\/p>\n\n\n\n<p>info@astimex.se<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glibenclamide Recip has blood sugar lowering effect by increasing the pancreas&#8217; own insulin production and possibly making this insulin more effective.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14395,14400,6140,14396,14401,14399,6142,6143,14394,14398,6141,14397],"class_list":["post-13426","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-glibenclamide","tag-benefits-of-glibenclamide-recip","tag-glibenclamide","tag-glibenclamide-recip","tag-glibenclamide-recip-side-effects","tag-glibenclamide-recip-tablet","tag-glibenclamide-side-effects","tag-glibenclamide-tablet","tag-what-glibenclamide-is-used-for","tag-what-glibenclamide-recip-is-used-for","tag-what-is-glibenclamide","tag-what-is-glibenclamide-recip"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13426"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13426\/revisions"}],"predecessor-version":[{"id":15509,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13426\/revisions\/15509"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}