{"id":13377,"date":"2021-09-07T05:59:27","date_gmt":"2021-09-07T05:59:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13377"},"modified":"2023-01-26T03:51:10","modified_gmt":"2023-01-26T03:51:10","slug":"gelofusine","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/gelofusine\/","title":{"rendered":"Gelofusine &#8211; Succinylated Gelatin (Modified Gelatin, Liquid) Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Gelofusine infusion&nbsp;Succinylated Gelatin (modified gelatin, liquid) Solution<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Is Gelofusine And What Is Gelofusine Used For<\/h2>\n\n\n\n<p>Gelofusine is a so-called volume replacement for&nbsp;plasma.&nbsp;This means that it replaces lost fluid in the blood circulation.<\/p>\n\n\n\n<p>Gelofusine is used to<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Replace blood and body fluid lost as a result of e.g.\u00a0an operation, an accident or a burn.\u00a0It can be used in combination with\u00a0blood transfusion\u00a0if needed\u00a0.<\/li><li>Prevent low\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0) which may occur with\u00a0spinal\u00a0or epidural anesthesia or due to the risk of extensive blood loss in connection with\u00a0surgery\u00a0.<\/li><li>In combination with other infusion fluids increase the circulating blood volume using e.g.\u00a0heart-lung machine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What You Need To Know Before You Use Gelofusine<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Gelofusine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to gelatin or any of the other ingredients of this medicine (listed in section 6)<\/li><li>If you are allergic to an\u00a0allergen\u00a0called galactose-\u03b1-1,3-galactose (alpha-gal) or to red meat (meat of mammals) and intestinal food<\/li><li>If your circulating blood volume is too large<\/li><li>If you have excess fluid in your body<\/li><li>If you have a certain type of\u00a0heart failure\u00a0(\u00a0acute\u00a0congestive\u00a0heart failure\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor, pharmacist, or nurse before receiving Gelofusine.<\/strong><\/p>\n\n\n\n<p>Tell your doctor<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have an allergic disease such as\u00a0asthma\u00a0.\u00a0You may then be at greater risk of developing an\u00a0allergic reaction\u00a0.<\/li><\/ul>\n\n\n\n<p>Due to the risk of possible cross-reactions, Gelofusine should not be given to you in the following cases<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you know you are allergic to red meat (meat of mammals) or intestinal foods.<\/li><li>If you have received a positive test result for\u00a0antibodies\u00a0(\u00a0IgE\u00a0) to\u00a0allergen\u00a0et alpha-gal.<\/li><\/ul>\n\n\n\n<p>Your doctor should take special care if you suffer from:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heart disease<\/li><li>High\u00a0blood pressure<\/li><li>Fluid in the lungs<\/li><li>Severe kidney disease<\/li><\/ul>\n\n\n\n<p>These conditions can get worse if you are given large amounts of fluid as a drip into a vein. The doctor prescribes the preparation with caution:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If the concentration of\u00a0sodium\u00a0or chloride in your blood is greatly increased<\/li><li>Of water and salts accumulate in the body which can cause swelling of the\u00a0tissue\u00a0are<\/li><li>If the blood&#8217;s coagulation capacity is significantly reduced<\/li><li>If you are older<\/li><\/ul>\n\n\n\n<p>During treatment with Gelofusine, the composition of the blood is monitored.&nbsp;If necessary, your doctor may also give you other medicines, such as salts and fluids.<\/p>\n\n\n\n<p><em><strong>Children<\/strong><\/em><\/p>\n\n\n\n<p>There is only limited experience with the use of Gelofusine in children.&nbsp;The doctor will give this medicine to children only if absolutely necessary.<\/p>\n\n\n\n<p><em><strong>Results for laboratory tests<\/strong><\/em><\/p>\n\n\n\n<p>Your doctor may take blood or urine samples before giving you Gelofusine.&nbsp;This is because some test results may be affected after you have received this medicine and may therefore be unreliable.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Gelofusine<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>It is especially important that your doctor knows if you are taking or receiving medicines that may cause&nbsp;sodium&nbsp;accumulation&nbsp;(eg&nbsp;spironolactone, triamterene, amiloride,&nbsp;ACE inhibitors&nbsp;such as&nbsp;captopril,&nbsp;or&nbsp;enalapril,&nbsp;corticosteroids&nbsp;such as&nbsp;cortisone,&nbsp;or non-steroidal anti-inflammatory drugs such as&nbsp;diclofenac&nbsp;).&nbsp;Concomitant use of this medicine may cause swelling of the arms, hands, legs, and feet (&nbsp;edema&nbsp;).&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding And Fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>Tell your doctor if you are pregnant.&nbsp;Gelofusine should be avoided during pregnancy due to possible allergic reactions.&nbsp;However, your doctor may give you this medicine in an emergency.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Tell your doctor if you are breastfeeding.&nbsp;There is limited information on the excretion of this medicine in breast milk, but based on its chemical properties it is unlikely that it will pass into breast milk.<\/p>\n\n\n\n<p>Your doctor will decide if you should stop breastfeeding or treat with this medicine after weighing the benefits of breastfeeding for your baby and the benefits of the treatment for you.<\/p>\n\n\n\n<p><em>Fertility<\/em><\/p>\n\n\n\n<p>There is no information on the effect of this medicine on the&nbsp;fertility&nbsp;of humans or animals.&nbsp;However, based on the properties of the constituents,&nbsp;fertility&nbsp;is&nbsp;unlikely to&nbsp;be affected.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>This medicine has no effect on the ability to drive and use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Gelofusine<\/h2>\n\n\n\n<p><span style=\"text-decoration: underline;\"><strong>Gelofusine uses<\/strong><\/span><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will only give you Gelofusine if treatment with preparations called crystalloids alone is not considered sufficient.<\/li><li>Your doctor will carefully adjust the\u00a0dose\u00a0of Gelofusine to prevent fluid overload.\u00a0This is especially true if you have problems with your lungs, heart, or circulation.<\/li><li><strong>Dosage<\/strong><ul><li>Gelofusine is given intravenously, ie.\u00a0by drip.<\/li><\/ul><\/li><li><em>Adults<\/em><ul><li>How much you get and for how long depends on how much blood or fluid you have lost and on your condition.<\/li><li>Your doctor will perform tests (eg on your blood and\u00a0blood pressure\u00a0) during treatment and\u00a0dose\u00a0one of Gelofusine will be adjusted according to your needs.\u00a0If necessary, you can also be given blood or packed\u00a0red blood cells.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Use For Children<\/h2>\n\n\n\n<p>There are only limited data from the use of this medicine in children.&nbsp;The doctor will only give this medicine to children if it is considered necessary for the child&#8217;s recovery.&nbsp;In these cases, the child&#8217;s clinical condition is taken into account and the treatment is monitored particularly closely.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Gelofusine Than You Should\u00a0<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>An overdose of Gelofusine can cause excessive blood volume in the body (\u00a0hypervolemia\u00a0) and fluid overload that can affect heart or lung function.<\/li><li>You may experience headaches and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/respiratory-difficulties-in-children\/\">difficulty breathing<\/a>.<\/li><li>In case of an overdose, the doctor will take the necessary measures.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible Gelofusine Side Effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>All plasma substitutes involve a small risk of allergic reactions, which are usually mild or moderate, but which in very few cases can also be serious.&nbsp;Such reactions are thought to be more common in patients with known allergic conditions such as&nbsp;asthma.&nbsp;For this reason, healthcare professionals will observe you carefully, especially at the beginning of&nbsp;infusion&nbsp;one.<\/p>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;can be serious.&nbsp;If you get any of the following&nbsp;side effects,&nbsp;talk to your doctor straight away:<\/strong><\/p>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic (anaphylactic \/ anaphylactoid) reactions, such as <ul><li>Difficulty breathing<\/li><li>Wheezing<\/li><li>Nausea<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/stomach-disease-diarrhea-and-vomiting\/\">Vomiting<\/a><\/li><li>Dizziness<\/li><li>Sweating<\/li><li>Feeling of pressure in the chest or throat<\/li><li>Abdominal <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a><\/li><li>Swelling of the neck and face<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Infusion&nbsp;one should be stopped immediately and you should be given the necessary care in case of an&nbsp;allergic reaction&nbsp;(see also section 2 &#8220;What you need to know before using Gelofusine&#8221;, especially for&nbsp;allergies&nbsp;involving the&nbsp;allergen&nbsp;et galactose-\u03b1-1,3-galactose (alpha-gal), red meat and offal).<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;include:<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of\u00a0red blood cells\u00a0and\u00a0protein\u00a0in the blood.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The blood does not coagulate as well as before and you may notice that you are bleeding more than before.<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 people):&nbsp;<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/palpitation\/\">Palpitation<\/a><\/li><li>Low\u00a0blood pressure<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">Fever<\/a><\/li><li>Chills<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><li>Vomiting<\/li><li>Abdominal pain<\/li><li>Decreased oxygen content in the blood which can cause dizziness<\/li><\/ul>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;are in children<\/strong><\/p>\n\n\n\n<p>There are no data on any differences in&nbsp;side effects&nbsp;in children.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How To Store Gelofusine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the label and outer carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Do not store above 25 \u00b0 C.\u00a0Do not freeze.<\/li><li>Do not use this medicine if you notice<ul><li>Turbidity or discoloration of the solution<\/li><li>That the packaging has leaked.<\/li><\/ul><\/li><li>Previously opened or partially used packaging of Gelofusine should be discarded.\u00a0Partially used bags should not be reconnected.<\/li><li>The product should be used immediately after opening.<\/li><\/ul>\n\n\n\n<p><strong>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents Of The Packaging And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are succinylated gelatin (modified gelatin, liquid) and sodium chloride<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>succinylated gelatin (modified gelatin, liquid)<\/td><td>40.0 g<\/td><\/tr><tr><td>sodium chloride<\/td><td>7.0 g<\/td><\/tr><tr><td>&nbsp;<\/td><td>&nbsp;<\/td><\/tr><tr><td><em>Electrolyte content<\/em><\/td><\/tr><tr><td>sodium<\/td><td>154 mmol<\/td><\/tr><tr><td>chloride<\/td><td>120 mmol<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>The other ingredients are water for injections,\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment\u00a0) and sodium hydroxide (for\u00a0pH\u00a0adjustment\u00a0).<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><td><em>Physico-chemical properties<\/em><\/td><\/tr><\/thead><tbody><tr><td>pH<\/td><td>7.4 \u00b1 0.3<\/td><\/tr><tr><td>osmolarity<\/td><td>274 mOsm \/ l<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Gelofusine is an\u00a0infusion solution, a solution given by\u00a0intravenous\u00a0drip (drip into a vein).<\/li><li>Gelofusine is a clear, colorless, or slightly yellowish\u00a0sterile\u00a0solution.<\/li><li>Available in:<ul><li>500 ml polyethylene bottles (Ecoflac) in packs of 10 bottles<\/li><li>Polypropylene bags (Ecobag) of 250 ml and 500 ml in packs of 20 bags<\/li><li>1000 ml polypropylene bags (Ecobag) in packs of 10 bags.<\/li><\/ul><\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p>B. Braun Melsungen AG<br>Carl-Braun-Str.\u00a01<br>34212 Melsungen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><em>Postal address<\/em><br>B. Braun Melsungen AG<br>34209 Melsungen, Germany<\/p>\n\n\n\n<p><strong>Information provided by:<\/strong><\/p>\n\n\n\n<p>B. Braun Medical AB<\/p>\n\n\n\n<p>Box 110<\/p>\n\n\n\n<p>182 12 Danderyd<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gelofusine is used to replenish blood and bodily fluids that have been lost due to an operation, an accident, or a burn. It can be used in place of or in addition to a blood transfusion.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14551,14557,14548,14552,2507,14558,14553,14556,14550,14549,14554,14555],"class_list":["post-13377","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-gelofusine","tag-benefits-of-succinylated-gelatin","tag-gelofusine","tag-gelofusine-side-effects","tag-liquid","tag-modified-gelatin","tag-succinylated-gelatin","tag-succinylated-gelatin-side-effects","tag-what-gelofusine-is-used-for","tag-what-is-gelofusine","tag-what-is-succinylated-gelatin","tag-what-succinylated-gelatin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13377","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13377"}],"version-history":[{"count":37,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13377\/revisions"}],"predecessor-version":[{"id":46565,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13377\/revisions\/46565"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13377"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13377"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13377"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}