{"id":13362,"date":"2021-09-07T05:47:14","date_gmt":"2021-09-07T05:47:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13362"},"modified":"2021-11-09T10:58:45","modified_gmt":"2021-11-09T10:58:45","slug":"gefitinib-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/gefitinib-accord\/","title":{"rendered":"Gefitinib Accord &#8211; Gefitinib uses, dose and side effects"},"content":{"rendered":"\n<p>250 mg&nbsp;film-coated tablets<br>gefitinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Gefitinib Accord is and what it is used for<\/h2>\n\n\n\n<p>Gefitinib Accord contains the active substance gefitinib which blocks a&nbsp;protein&nbsp;called&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor (EGFR).&nbsp;This&nbsp;protein&nbsp;is involved in the growth and spread of cancer cells.<\/p>\n\n\n\n<p>Gefitinib Accord is used to treat adults with non-small cell lung cancer.&nbsp;This cancer is a disease in which malignant (cancerous) cells form in the lung tissue.<\/p>\n\n\n\n<p>Gefitinib contained in Gefitinib Accord may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking Gefitinib Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Gefitinib Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to gefitinib or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are breast-feeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Gefitinib Accord:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had other lung problems before.&nbsp;Some lung problems may be aggravated by treatment with Gefitinib Accord<\/li><li>if you have ever had liver problems.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Gefitinib Accord is not intended for use in children and adolescents below 18 years.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Gefitinib Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>In particular, tell your doctor or pharmacist if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Phenytoin&nbsp;or carbamazepine (for&nbsp;epilepsy&nbsp;).<\/li><li>Rifampicin (for&nbsp;tuberculosis&nbsp;&#8211; TBC).<\/li><li>Itraconazole (for fungal infections).<\/li><li>Barbiturates&nbsp;(a type of medicine used to treat sleep problems).<\/li><li>Herbal medicines containing&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;, which is used for mild depression).<\/li><li>Proton pump inhibitors&nbsp;, H&nbsp;<sub>2<\/sub>&nbsp;&#8211;&nbsp;antagonists&nbsp;and antacids (for&nbsp;stomach ulcers&nbsp;, stomach upset, heartburn and to reduce stomach acid).<\/li><\/ul>\n\n\n\n<p>These medicines may affect the effect of Gefitinib Accord.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Warfarin&nbsp;(a so-called&nbsp;oral&nbsp;anticoagulant to prevent blood clots).&nbsp;If you are taking a medicine containing this active substance, your doctor may need to take blood samples more often.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before taking Gefitinib Accord.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant, pregnant, or breastfeeding, ask your doctor for advice before taking this medicine.&nbsp;It is recommended that you avoid becoming pregnant while being treated with Gefitinib Accord as Gefitinib Accord may harm your baby.<\/p>\n\n\n\n<p>For your baby&#8217;s safety, do not use Gefitinib Accord if you are breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Should you feel weak while using this medicine, you should be careful when driving or using machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Gefitinib Accord contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Gefitinib Accord<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is 1 tablet (250 mg) daily.<\/li><li>Take the tablet at about the same time each day.<\/li><li>You can take the tablet with or without food.<\/li><li>Do not take antacids (to reduce the amount of acid in your stomach) 2 hours before or 1 hour after taking Gefitinib Accord.<\/li><\/ul>\n\n\n\n<p>If you have problems swallowing the tablet, you can dissolve it in half a glass of water that does not contain carbon dioxide.&nbsp;Do not use any other liquid.&nbsp;Do not crush the tablet.&nbsp;Swirl the glass until the tablet has dissolved.&nbsp;This can take up to 20 minutes.&nbsp;Then drink the liquid immediately.&nbsp;To be sure that you have ingested all the medicine, rinse the glass very thoroughly with half a glass of water and drink from it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Gefitinib Accord than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;If a child has ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Gefitinib Accord<\/h2>\n\n\n\n<p>What to do if you forget to take a tablet depends on how much time is left until the next&nbsp;dose.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If it is 12 hours or more until the next dose: take the forgotten tablet as soon as you remember that you forgot it.&nbsp;Then take the next&nbsp;dose&nbsp;at the usual time.<\/li><li>If it is less than 12 hours until you take the next dose: skip the missed&nbsp;dose&nbsp;.&nbsp;Then take the next&nbsp;dose&nbsp;at the usual time.<\/li><\/ul>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;(two&nbsp;doses&nbsp;at the same time) to compensate for a missed&nbsp;dose.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact your doctor immediately if you get any of the following&nbsp;side effects&nbsp;&#8211; you may need immediate medical attention:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reaction&nbsp;(common) especially if the symptoms include swelling of the face, lips, tongue or throat, difficulty swallowing, hives,&nbsp;hives&nbsp;and difficulty breathing.<\/li><li>Severe shortness of breath, or sudden worsening of shortness of breath and possibly also cough and fever.&nbsp;This may mean that you have an&nbsp;inflammation&nbsp;of the lungs called &#8220;interstitial lung disease&#8221;.&nbsp;It affects approximately 1 in 100 patients taking Gefitinib Accord and can be life threatening.<\/li><li>Severe skin reactions (rare) that affect large areas of the body.&nbsp;Signs of this can be&nbsp;redness&nbsp;, pain, sores, blisters and flaking of the skin.&nbsp;Lips, nose, eyes and genitals can also be affected.<\/li><li>Dehydration (common) caused by prolonged or severe diarrhea, vomiting, nausea or loss of appetite.<\/li><li>Eye problems (rare) such as pain, red eyes, watery eyes, photosensitivity, changes in vision or that the&nbsp;eyelashes&nbsp;grow inwards.&nbsp;This may mean that you have a wound on the surface of the eye (cornea).<\/li><\/ul>\n\n\n\n<p><strong>Talk to your doctor as soon as possible if you get any of the following side effects: Very common: may affect more than 1 in 10 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><li>Vomiting<\/li><li>Nausea<\/li><li>Skin reactions, such as acne-like rashes that sometimes itch and include dry and \/ or cracked skin<\/li><li>Loss of appetite<\/li><li>Weakness<\/li><li>Red or sore mouth<\/li><li>Elevation of the liver enzyme&nbsp;alanine aminotransferase&nbsp;in blood tests &#8211; if too high, your doctor may urge you to stop taking Gefitinib Accord.<\/li><\/ul>\n\n\n\n<p><strong>Common: may affect up to 1 in 10 users<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dry mouth<\/li><li>Dry, red or itchy eyes<\/li><li>Red and sore eyelids<\/li><li>Nail problems<\/li><li>Hair loss<\/li><li>Fever<\/li><li>Bleeding (eg nosebleeds or blood in the urine)<\/li><li>Protein&nbsp;in the urine (as seen in urine samples)<\/li><li>Elevation of&nbsp;bilirubin&nbsp;and the liver enzyme&nbsp;aspartate aminotransferase&nbsp;in blood tests &#8211; if too high, your doctor may urge you to stop taking Gefitinib Accord<\/li><li>Increased levels of&nbsp;creatinine&nbsp;in blood tests (shows how your kidneys are working)<\/li><li>Cystitis&nbsp;(burning sensation when urinating and frequent, acute urges).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the pancreas.&nbsp;It is characterized by very severe pain in the upper abdomen and severe nausea and vomiting.<\/li><li>Inflammation&nbsp;of the liver.&nbsp;The symptoms may be a general feeling of illness with or without any jaundice (the skin and whites of the eyes turn yellow).&nbsp;This&nbsp;side effect&nbsp;is less common, but some patients have died from it.<\/li><li>Holes (&nbsp;perforation&nbsp;are) in the gastrointestinal tract.<\/li><\/ul>\n\n\n\n<p><strong>Rare: may affect up to 1 in 1,000 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the blood vessels in the skin.&nbsp;It may look like bruises or blemishes on the skin that do not fade away.<\/li><li>Hemorrhagic&nbsp;cystitis&nbsp;(burning sensation when urinating and frequent, acute urination with blood in the urine).<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Gefitinib Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>After dispersion (mixing) in water, the&nbsp;mixture&nbsp;should&nbsp;be used within 90 minutes.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is gefitinib.&nbsp;Each tablet contains 250 mg of gefitinib.<\/li><li>Other ingredients are:Tablet core:&nbsp;Lactose monohydrate&nbsp;, microcrystalline cellulose, croscarmellose sodium, povidone, sodium lauryl sulphate, magnesium stearate.Tablet cover: poly (vinyl alcohol), macrogol, talc, titanium dioxide (E171), yellow iron oxide (E172) and red iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Gefitinib Accord is a brown, film-coated, round, biconvex tablet, debossed with \u201cLP100\u201d on one side and smooth on the other.&nbsp;The tablet has a diameter of about 11.13 mm.<\/p>\n\n\n\n<p>Pack size of 30 x 1 tablets in PVC \/ PVDC \u2011 Al \u2011 perforated unit dose blister packed in PET \/ Al \u2011 bag in a carton.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 KV Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited,<\/p>\n\n\n\n<p>Sage House, 319 Pinner Road, North Harrow,<\/p>\n\n\n\n<p>Middlesex, HA1 4HF, UK<\/p>\n\n\n\n<p>LABORATORI FUNDACI\u00d3 DAU<\/p>\n\n\n\n<p>C \/ C, 12-14 Pol.&nbsp;Ind.&nbsp;Zona Franca,<\/p>\n\n\n\n<p>Barcelona, \u200b\u200b08040, Spain<\/p>\n\n\n\n<p>Wessling Hungary Kft.<\/p>\n\n\n\n<p>Anonymous u. 6<\/p>\n\n\n\n<p>Budapest, 1045<\/p>\n\n\n\n<p>Hungary<\/p>\n\n\n\n<p>Pharmadox Healthcare Ltd<\/p>\n\n\n\n<p>KW20A Kordin Industrial Park<\/p>\n\n\n\n<p>Paola, PLA 3000<\/p>\n\n\n\n<p>Malta<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gefitinib Accord contains the active substance gefitinib which blocks a protein called epidermal growth factor receptor (EGFR). This protein is involved in the growth and spread of cancer cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[12366,14593,12361,14589,14594,14592,12364,14588,14591,12363,12362,14590],"class_list":["post-13362","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-gefitinib","tag-benefits-of-gefitinib-accord","tag-gefitinib","tag-gefitinib-accord","tag-gefitinib-accord-side-effects","tag-gefitinib-accord-tablet","tag-gefitinib-tablet","tag-side-effects-of-gefitinib","tag-what-gefitinib-accord-is-used-for","tag-what-gefitinib-is-used-for","tag-what-is-gefitinib","tag-what-is-gefitinib-accord"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13362"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13362\/revisions"}],"predecessor-version":[{"id":15585,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13362\/revisions\/15585"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}