{"id":13353,"date":"2021-09-06T07:27:04","date_gmt":"2021-09-06T07:27:04","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13353"},"modified":"2021-11-09T10:59:07","modified_gmt":"2021-11-09T10:59:07","slug":"gazyvaro","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/gazyvaro\/","title":{"rendered":"Gazyvaro &#8211; Obinutuzumab uses, dose and side effects"},"content":{"rendered":"\n<p>1000 mg concentrate for solution for infusion<br>obinutuzumab<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Gazyvaro is and what it is used for<\/h2>\n\n\n\n<p><strong><em>What Gazyvaro is<\/em><\/strong><\/p>\n\n\n\n<p>Gazyvaro contains the active substance obinutuzumab, which belongs to a group of medicines called &#8216;monoclonal antibodies.&nbsp;Antibodies&nbsp;work by binding to specific targets in your body.<\/p>\n\n\n\n<p><strong><em>What Gazyvaro is used for<\/em><\/strong><\/p>\n\n\n\n<p>Gazyvaro can be used in adults to treat two different types of cancer<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Chronic lymphocytic leukemia<\/strong>&nbsp;(also called &#8220;CLL&#8221;)<ul><li>Gazyvaro is used in patients who have not previously received any treatment for&nbsp;CLL&nbsp;and who have other conditions that make it unlikely that they could handle a full&nbsp;dose&nbsp;of another medicine used to treat&nbsp;KLL&nbsp;called fludarabine.<\/li><li>Gazyvaro is used in combination with another anticancer medicine called chlorambucil.<\/li><\/ul><\/li><li><strong>Follicular&nbsp;lymphoma&nbsp;<\/strong>(also called &#8220;FL&#8221;)<ul><li>Gazyvaro is used in patients who have not received any treatment for FL<\/li><li>Gazyvaro is used in patients who have received at least one previous treatment with a drug called rituximab and whose FL has returned or worsened during or after this treatment.<\/li><li>At the start of treatment with FL, Gazyvaro is used with other anticancer medicines.<\/li><li>Gazyvaro can be used as the only medicine for up to 2 years as a &#8220;maintenance treatment&#8221;.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>How Gazyvaro works<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>KLL&nbsp;and FL are types of cancer that affect&nbsp;white blood cells&nbsp;called &#8220;B lymphocytes&#8221;.&nbsp;The affected &#8220;B lymphocytes&#8221; divide too quickly and live too long.&nbsp;Gazyvaro binds to the surface of the&nbsp;B lymphocytes&nbsp;, leading to their death.<\/li><li>When Gazyvaro is given to patients with&nbsp;CLL&nbsp;or FL together with other anticancer medicines, it takes time for their disease to worsen.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you are treated with Gazyvaro<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not be treated with Gazyvaro if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to obinutuzumab or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If you are not sure, talk to your doctor or nurse before giving Gazyvaro.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to a doctor or nurse before you are treated with Gazyvaro if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have an&nbsp;infection&nbsp;, or have previously had an&nbsp;infection&nbsp;that was prolonged or constantly coming back<\/li><li>have you ever taken, or received, medicines that affect the immune system (such as&nbsp;chemotherapy drugs&nbsp;or immunosuppressants)<\/li><li>you are taking any medicine for high&nbsp;blood pressure&nbsp;or medicines that are used to thin your blood &#8211; your doctor may need to change how you take these<\/li><li>you have ever had heart problems<\/li><li>you have ever had problems with the brain (such as memory problems, movement problems or sensations in the body, problems with vision)<\/li><li>you have ever had breathing or lung problems<\/li><li>you have ever had&nbsp;hepatitis&nbsp;B, a type of liver disease<\/li><li>you should undergo a vaccination or know that you may need one in the near future.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor or nurse before taking Gazyvaro.<\/p>\n\n\n\n<p><strong>Be aware of the following&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Gazyvaro can cause serious&nbsp;side effects&nbsp;that you must tell your doctor or nurse immediately.&nbsp;These include:<\/p>\n\n\n\n<p><strong>Infusion-related reactions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor or nurse immediately if you get any of the infusion-related reactions listed at the beginning of section 4. Infusion-related reactions may occur during&nbsp;infusion&nbsp;one up to 24 hours after&nbsp;infusion&nbsp;one.<\/li><li>If you get an infusion-related reaction, you may need further treatment or your&nbsp;infusion&nbsp;may&nbsp;need to be slowed down or stopped.&nbsp;When the reactions disappear, or improve, the&nbsp;infusion&nbsp;can be&nbsp;continued.&nbsp;These reactions are more likely to occur during the first&nbsp;infusion&nbsp;.&nbsp;Your doctor may decide to stop using Gazyvaro if you get a strong infusion reaction.<\/li><li>Before each&nbsp;infusion&nbsp;of Gazyvaro, you will be given medicines to help reduce any infusion-related reactions or &#8220;tumor light syndrome&#8221;.&nbsp;Tumor light syndrome is a potentially life-threatening complication caused by chemical changes in the blood that occur due to the breakdown of dying cancer cells (see section 3).<\/li><\/ul>\n\n\n\n<p><strong>Progressive&nbsp;multifocal&nbsp;leukoencephalopathy (also called &#8220;PML&#8221;)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>PML is a very rare and life-threatening&nbsp;brain&nbsp;infection&nbsp;that has been reported in very few patients treated with Gazyvaro.<\/li><li>Tell your doctor or nurse immediately if you have memory loss, difficulty speaking, difficulty walking or problems with your vision.<\/li><li>If you have had any of these symptoms before treatment with Gazyvaro, tell your doctor immediately if you notice any changes in them.&nbsp;You may need medical treatment.<\/li><\/ul>\n\n\n\n<p><strong>Infection&nbsp;is<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell&nbsp;your&nbsp;doctor or nurse immediately if you get any signs of&nbsp;infection&nbsp;after your treatment with Gazyvaro (see \u201cInfections\u201d in section 4).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give Gazyvaro to children or adolescents under 18 years of age, as there is no information on the use of Gazyvaro in these age groups.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Gazyvaro<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you have recently taken or might take any other medicines.&nbsp;This includes over-the-counter and herbal medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your doctor or nurse if you are pregnant, think you may be pregnant or are planning to have a baby.&nbsp;They will help you weigh the benefits of continuing to be treated with Gazyvaro against the risk to your child.<\/li><li>If you become pregnant during treatment with Gazyvaro, tell your doctor or nurse as soon as possible.&nbsp;This is because treatment with Gazyvaro can affect your or your child&#8217;s health.<\/li><\/ul>\n\n\n\n<p><strong><em>Breast-feeding<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not breast-feed during treatment with Gazyvaro or for 18 months after stopping treatment with Gazyvaro, as small amounts of the medicine may pass into breast milk.<\/li><\/ul>\n\n\n\n<p><strong>Contraceptive<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Use an effective method of contraception while you are being treated with Gazyvaro.<\/li><li>Continue to use effective contraception for 18 months after stopping treatment with Gazyvaro.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Gazyvaro is unlikely to affect your ability to drive, cycle, or use any tools or machines.&nbsp;However, if you get an infusion-related reaction (see section 4), do not drive, cycle or use tools or machines until the reaction has disappeared.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How Gazyvaro is given<\/h2>\n\n\n\n<p><strong>How Gazyvaro is given<\/strong><\/p>\n\n\n\n<p>Gazyvaro is given under the supervision of a doctor who has experience in the treatment.&nbsp;It is given into a vein as a drip (&nbsp;intravenous&nbsp;infusion&nbsp;) over several hours.<\/p>\n\n\n\n<p><strong>Gazyvaro treatment<\/strong><\/p>\n\n\n\n<p><strong>Chronic lymphocytic leukemia<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You will be given 6 cycles of treatment with Gazyvaro in combination with another anticancer medicine called chlorambucil.&nbsp;Each cycle is 28 days long.<\/li><li>On day 1 of your first cycle, you will receive a portion of your first Gazyvaro&nbsp;dose&nbsp;of 100 milligrams (mg) very slowly and your doctor \/ nurse will monitor you closely for infusion-related reactions.<\/li><li>If you do not get an infusion-related reaction after the first small&nbsp;dose&nbsp;of your first&nbsp;dose&nbsp;, you can receive the rest of your first&nbsp;dose&nbsp;(900 mg) on \u200b\u200bthe same day.<\/li><li>If you get an infusion-related reaction after the first small part of your first&nbsp;dose&nbsp;, you will receive the rest of your first&nbsp;dose&nbsp;on day 2.<\/li><\/ul>\n\n\n\n<p>A typical treatment schedule is shown below.<\/p>\n\n\n\n<p>Treatment cycle 1 &#8211; will include three&nbsp;doses&nbsp;of Gazyvaro during the 28 days:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Day 1 &#8211; part of your first&nbsp;dose&nbsp;(100 mg)<\/li><li>Day 2 or day 1 (continued) &#8211; remaining part of the first&nbsp;dose&nbsp;(900 mg)<\/li><li>Day 8 &#8211; full&nbsp;dose&nbsp;(1000 mg)<\/li><li>Day 15 &#8211; full&nbsp;dose&nbsp;(1000 mg)<\/li><\/ul>\n\n\n\n<p>Treatment cycles 2, 3, 4, 5, and 6 &#8211; there will only be one&nbsp;dose&nbsp;of Gazyvaro during the 28 days:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Day 1 &#8211; full&nbsp;dose&nbsp;(1000 mg)<\/li><\/ul>\n\n\n\n<p><strong>Follicular&nbsp;lymphoma<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You will be given 6 or 8 cycles of treatment with Gazyvaro in combination with other anticancer medicines &#8211; each cycle lasts for 28 or 21 days depending on the other medicines given with Gazyvaro.<\/li><li>This initial phase is followed by a &#8220;maintenance phase&#8221; &#8211; during this time you will be given Gazyvaro every two months for up to 2 years as long as your illness does not worsen.&nbsp;Depending on your disease status, your doctor will decide after the initial treatment cycles whether to receive treatment during the maintenance phase.<\/li><li>A typical treatment schedule is shown below.<\/li><\/ul>\n\n\n\n<p><strong>Initial phase<\/strong><\/p>\n\n\n\n<p>Treatment cycle 1 &#8211; it includes three&nbsp;doses&nbsp;of Gazyvaro during the 28 or 21 days, depending on which another medicine is given with Gazyvaro:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Day 1 &#8211; full&nbsp;dose&nbsp;(1000 mg)<\/li><li>Day 8 &#8211; full&nbsp;dose&nbsp;(1000 mg)<\/li><li>Day 15 &#8211; full&nbsp;dose&nbsp;(1000 mg)<\/li><\/ul>\n\n\n\n<p>Treatment cycle 2-6 or 2-8 &#8211; there will only be one&nbsp;dose&nbsp;of Gazyvaro during the 28 or 21 days, depending on which another medicine is given with Gazyvaro:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Day 1 &#8211; full&nbsp;dose&nbsp;(1000 mg)<\/li><\/ul>\n\n\n\n<p><strong>Maintenance phase<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Full&nbsp;dose&nbsp;(1000 mg) once every two months for up to 2 years as long as your disease does not worsen<\/li><\/ul>\n\n\n\n<p><strong>Medicines are given before each&nbsp;infusion<\/strong><\/p>\n\n\n\n<p>Before each&nbsp;infusion&nbsp;of Gazyvaro, you will be given medicines that reduce the risk of infusion-related reactions or tumor lysis syndrome.&nbsp;These can be the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liquid<\/li><li>drugs to lower fever<\/li><li>analgesics (&nbsp;analgesics&nbsp;)<\/li><li>drugs to reduce&nbsp;inflammation&nbsp;(&nbsp;cortisone&nbsp;)<\/li><li>medicines to reduce an&nbsp;allergic reaction&nbsp;(&nbsp;antihistamines&nbsp;)<\/li><li>drugs to prevent tumor lysis syndrome (such as allopurinol)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you miss a treatment session with Gazyvaro<\/h2>\n\n\n\n<p>Book a new appointment as soon as possible if you miss a treatment, as it is important to follow the dosing schedule for this medicine to be as effective as possible.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;The following&nbsp;side effects&nbsp;have been reported with this medicine:<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Infusion-related reactions<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse immediately if you get any of the following symptoms during your&nbsp;infusion&nbsp;or up to 24 hours after your&nbsp;infusion.<\/p>\n\n\n\n<p>Most commonly reported:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea<\/li><li>fatigue<\/li><li>dizziness<\/li><li>headache<\/li><li>diarrhea<\/li><li>fever,&nbsp;flushing&nbsp;or chills<\/li><li>vomiting<\/li><li>respiratory distress<\/li><li>low or high&nbsp;blood pressure<\/li><li>palpitation<\/li><li>chest discomfort<\/li><\/ul>\n\n\n\n<p>Uncommonly reported:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>irregular heartbeats<\/li><li>swelling of the throat or respiratory tract<\/li><li>wheezing, difficulty breathing, tightness in the chest or throat irritation<\/li><\/ul>\n\n\n\n<p>If you get any of the above, tell your doctor or nurse immediately.<\/p>\n\n\n\n<p><strong>Progressive&nbsp;multifocal&nbsp;leukoencephalopathy<\/strong><\/p>\n\n\n\n<p>PML is a very unusual and life-threatening&nbsp;brain&nbsp;infection&nbsp;that has been reported with Gazyvaro.<\/p>\n\n\n\n<p>Tell your doctor or nurse immediately if you have any<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>memory loss<\/li><li>difficulty speaking<\/li><li>difficulty walking<\/li><li>problem with your vision<\/li><\/ul>\n\n\n\n<p>If you have had any of these symptoms before treatment with Gazyvaro, tell your doctor immediately if you notice any changes in them.&nbsp;You may need medical treatment.<\/p>\n\n\n\n<p><strong>Infection&nbsp;is<\/strong><\/p>\n\n\n\n<p>You may be more likely to get an&nbsp;infection&nbsp;during and after treatment with Gazyvaro.&nbsp;These are often colds, but there have been cases of more serious&nbsp;infections.&nbsp;A liver disease called &#8220;hepatitis B&#8221; has also been reported to recur in patients with a&nbsp;history of hepatitis&nbsp;B.<\/p>\n\n\n\n<p>Contact your doctor or nurse immediately if you get any symptoms of infection&nbsp;during and after your Gazyvara treatment.&nbsp;These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever<\/li><li>cough<\/li><li>chest pain<\/li><li>fatigue<\/li><li>painful rash<\/li><li>sore throat<\/li><li>burning sensation when urinating<\/li><li>feeling of weakness or general feeling of illness.<\/li><\/ul>\n\n\n\n<p>If you have had a recurrent or&nbsp;chronic&nbsp;infection&nbsp;before treatment with Gazyvaro, tell your doctor.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever<\/li><li>lung infection<\/li><li>headache<\/li><li>joint pain, back pain<\/li><li>feeling weak<\/li><li>feeling tired<\/li><li>pain in arms and legs<\/li><li>diarrhea, constipation<\/li><li>insomnia<\/li><li>hair loss,&nbsp;itching<\/li><li>urinary tract infection, rhinitis and sore throat,&nbsp;shingles<\/li><li>changes in blood samples:<ul><li>anemia&nbsp;(low&nbsp;red blood cell count&nbsp;)<\/li><li>low number of all types of&nbsp;white blood cells&nbsp;(total)<\/li><li>low number of&nbsp;neutrophils&nbsp;(a type of&nbsp;white blood cell&nbsp;)<\/li><li>low&nbsp;platelet count&nbsp;(a type of&nbsp;blood cell&nbsp;that helps your blood clot)<\/li><\/ul><\/li><li>upper respiratory tract infection (&nbsp;infection&nbsp;of the nose, throat, larynx and sinuses), cough<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cold sores<\/li><li>depression, anxiety<\/li><li>influenza<\/li><li>weight gain<\/li><li>runny nose or nasal congestion<\/li><li>eczema<\/li><li>pain in the mouth or throat<\/li><li>musculoskeletal pain in the chest<\/li><li>skin cancer (&nbsp;squamous&nbsp;cell&nbsp;carcinoma&nbsp;, basal cell carcinoma)<\/li><li>skeletal pain<\/li><li>irregular heartbeat (&nbsp;atrial fibrillation&nbsp;)<\/li><li>problems urinating, urinary incontinence<\/li><li>high&nbsp;blood pressure<\/li><li>digestive problems (eg heartburn),&nbsp;hemorrhoids<\/li><li>changes in blood samples:<ul><li>low number of&nbsp;lymphocytes&nbsp;(a type of&nbsp;white blood cell&nbsp;), fever associated with low levels of&nbsp;neutrophils&nbsp;(a type of&nbsp;white blood cell&nbsp;)<\/li><li>increase in&nbsp;potassium&nbsp;,&nbsp;phosphate&nbsp;or&nbsp;uric acid&nbsp;&#8211; which can cause kidney problems (part of tumor lysis syndrome)<\/li><li>reduction of&nbsp;potassium<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A hole in the stomach or intestines (&nbsp;gastrointestinal&nbsp;perforation&nbsp;, especially in cases where the cancer affects the gastrointestinal tract)<\/li><\/ul>\n\n\n\n<p>Tell your doctor or nurse if you notice any of the&nbsp;side effects&nbsp;listed above.<br><\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Gazyvaro<\/h2>\n\n\n\n<p>Gazyvaro will be stored by healthcare professionals in hospitals or clinics.&nbsp;The storage instructions are as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze.<\/li><li>Store in the outer carton.&nbsp;Sensitive to light.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Your doctor or nurse will discard any medicines that are no longer in use.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is obinutuzumab: 1000 mg \/ 40 ml per&nbsp;vial&nbsp;corresponding to a concentration of 25 mg \/ ml before dilution.<\/li><li>The other ingredients are histidine, histidine hydrochloride monohydrate, trehalose dihydrate, poloxamer 188 and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Gazyvaro is a concentrate for&nbsp;infusion&nbsp;solution for&nbsp;infusion.&nbsp;It is a colorless to slightly brownish liquid.&nbsp;Gazyvaro is available in a pack of 1&nbsp;glass&nbsp;vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Roche Registration GmbH<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Roche Pharma AG<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>D-79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>NV Roche SATel: +32 (0) 2 525 82 11<\/td><td><strong>Lithuania<\/strong>UAB \u201cRoche Lietuva\u201dTel: +370 5 2546799<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Rosh BULGARIA LOODETel: +359 2 818 44 44<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>(See \/ See Belgium \/ Belgium)<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Roche sroTel: +420 &#8211; 2 20382111<\/td><td><strong>Hungary<\/strong>Roche (Hungary) Kft.Tel: +36 &#8211; 23 446 800<\/td><\/tr><tr><td><strong>Denmark<\/strong>Roche a \/ sTel: +45 &#8211; 36 39 99 99<\/td><td><strong>Malta<\/strong>(See Ireland)<\/td><\/tr><tr><td><strong>Germany<\/strong>Roche Pharma AGTel: +49 (0) 7624 140<\/td><td><strong>The Netherlands<\/strong>Roche Nederland BVTel: +31 (0) 348 438050<\/td><\/tr><tr><td><strong>Eesti<\/strong>Roche Eesti O\u00dcTel: + 372 &#8211; 6 177 380<\/td><td><strong>Norway<\/strong>Roche Norge ASTel: +47 &#8211; 22 78 90 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Roche (Hellas) AE:\u0397\u03bb: +30 210 61 66 100<\/td><td><strong>Austria<\/strong>Roche Austria GmbHTel: +43 (0) 1 27739<\/td><\/tr><tr><td><strong>Spain<\/strong>Roche Farma SATel: +34 &#8211; 91 324 81 00<\/td><td><strong>Poland<\/strong>Roche Polska Sp.z ooTel: +48 &#8211; 22 345 18 88<\/td><\/tr><tr><td><strong>France<\/strong>RocheTel: +33 (0) 1 47 61 40 00<\/td><td><strong>Portugal<\/strong>Roche Pharmac\u00eautica Chemica, LdaTel: +351 &#8211; 21 425 70 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Roche dooTel: + 385 1 47 22 333<\/td><td><strong>Romania<\/strong>Roche Rom\u00e2nia SRLTel: +40 21 206 47 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Roche Products (Ireland) Ltd.Tel: +353 (0) 1 469 0700<\/td><td><strong>Slovenia<\/strong>Roche pharmacevtska dru\u017eba dooTel: +386 &#8211; 1 360 26 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Roche a \/ sc \/ o Icepharma hfPhone: +354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Roche Slovensko, sroTel: +421 &#8211; 2 52638201<\/td><\/tr><tr><td><strong>Italy<\/strong>Roche SpATel: +39 &#8211; 039 2471<\/td><td><strong>Finland \/ Finland<\/strong>Roche OyPuh \/ Tel: +358 (0) 10 554 500<\/td><\/tr><tr><td><strong>\u038e\u03c0\u03c1\u03bf\u03c2<\/strong>\u0393.\u0391.\u03a3\u03c4\u03b1\u03bc\u03ac\u03c4\u03b7\u03c2 &amp; \u03a3\u03b9\u03b1 \u039b\u03c4\u03b4.:\u0397\u03bb: +357 &#8211; 22 76 62 76<\/td><td><strong>Sweden<\/strong>Roche ABTel: +46 (0) 8 726 1200<\/td><\/tr><tr><td><strong>Latvia<\/strong>Roche Latvija SIATel: +371 &#8211; 6 7039831<\/td><td><strong>United Kingdom<\/strong>Roche Products Ltd.Tel: +44 (0) 1707 366000<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Gazyvaro contains the active substance obinutuzumab, which belongs to a group of medicines called &#8216;monoclonal antibodies. Antibodies work by binding to specific targets in your body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2207],"tags":[14611,14605,14607,14610,14602,14606,14609,14608,14603,14604],"class_list":["post-13353","post","type-post","status-publish","format-standard","hentry","category-medicines","category-g","tag-benefits-of-gazyvaro","tag-benefits-of-obinutuzumab","tag-gazyvaro","tag-gazyvaro-side-effects","tag-obinutuzumab","tag-obinutuzumab-side-effects","tag-what-gazyvaro-is-used-for","tag-what-is-gazyvaro","tag-what-is-obinutuzumab","tag-what-obinutu-is-used-forzumab"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13353"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13353\/revisions"}],"predecessor-version":[{"id":15588,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13353\/revisions\/15588"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}